Cargando…

Identification of novel ligands interacting with kappa opioid receptors

Detalles Bibliográficos
Autores principales:	Spetea, Mariana, Asim, Muhammad F, Berzetei-Gurske, Ilona P, Wolber, Gerhard, Schmidhammer, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Meeting Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194247/ http://dx.doi.org/10.1186/1471-2210-11-S2-A15

Ejemplares similares

A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids
por: Asim, Muhammad Faheem, et al.
Publicado: (2010)

Discovery and biological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist
por: Spetea, Mariana, et al.
Publicado: (2012)

Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors
por: Asim, Muhammad F, et al.
Publicado: (2008)

Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities
por: Schmidhammer, Helmut, et al.
Publicado: (2020)

Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies
por: Spetea, Mariana, et al.
Publicado: (2011)

Development of novel N-methyl and N-allyl-substituted oxazolomorphinans and their interaction with opioid receptors
por: Sipos, Attila, et al.
Publicado: (2011)

Synthesis, opioid receptor binding profile and SAR studies of 14-alkoxy-substituted indolo- and benzofuromorphinans
por: Staaf, Alexander, et al.
Publicado: (2008)

5-Benzyl substituted 14-methoxymetopon, a high affinity μ opioid receptor agonist with potent antinociceptive activity in mice
por: Spetea, Mariana, et al.
Publicado: (2008)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
por: Puls, Kristina, et al.
Publicado: (2022)

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery
por: Spetea, Mariana, et al.
Publicado: (2020)

Efficacy of systemic HS-198, an analogue of oxymorphone, on cancer pain-related behaviour in mice
por: Asim, Muhammad F, et al.
Publicado: (2011)

In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice
por: Lattanzi, Roberta, et al.
Publicado: (2018)

In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist
por: Puls, Kristina, et al.
Publicado: (2022)

Biological, pharmacological and immunological activities of novel 6-amino-acid-substituted 14-alkoxy-N-methylmorphinans
por: Guerrieri, Elena, et al.
Publicado: (2011)

N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists
por: Dumitrascuta, Maria, et al.
Publicado: (2020)

Influence of the 14-alkoxy group and the substitution in position 5 in N-methyl-14-alkoxymorphinan-6-ones on in vitro and in vivo pharmacological activities
por: Haddou, Tanila Ben, et al.
Publicado: (2012)

Introduction of a 6-cyano group in 14-oxygenated N-methylmorphinans influences in vitro and in vivo pharmacological activities
por: Follia, Valeria, et al.
Publicado: (2011)

μ Opioid receptor: novel antagonists and structural modeling
por: Kaserer, Teresa, et al.
Publicado: (2016)

Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile
por: Schmidhammer, Helmut, et al.
Publicado: (2012)

Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists
por: Noha, Stefan M., et al.
Publicado: (2017)

In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel μ opioid analgesic with reduced propensity to alter motor function
por: Spetea, Mariana, et al.
Publicado: (2010)

Activation of kappa opioid receptors reduces seizure activity in a dose-dependent way
por: Zangrandi, Luca, et al.
Publicado: (2012)

Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure–Activity Relationships
por: Erli, Filippo, et al.
Publicado: (2017)

Solving an Old Puzzle: Elucidation and Evaluation of the Binding Mode of Salvinorin A at the Kappa Opioid Receptor
por: Puls, Kristina, et al.
Publicado: (2023)

Pharmacological profiles of opioid ligands at Kappa opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2006)

Activation of kappa opioid receptors reduces EEG seizure activity in a mouse model of temporal lobe epilepsy
por: Zangrandi, Luca, et al.
Publicado: (2011)

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt(1)]DALDA, and KGOP01, Binding to the Mu Opioid Receptor
por: Dumitrascuta, Maria, et al.
Publicado: (2020)

Pharmacological Investigations of N-Substituent Variation in Morphine and Oxymorphone: Opioid Receptor Binding, Signaling and Antinociceptive Activity
por: Ben Haddou, Tanila, et al.
Publicado: (2014)

Exploring pharmacological activities and signaling of morphinans substituted in position 6 as potent agonists interacting with the μ opioid receptor
por: Ben Haddou, Tanila, et al.
Publicado: (2014)

Unveiling 7-Hydroxymitragynine as the Key Active Metabolite of Mitragynine and the Promise for Creating Novel Pain Relievers
por: Spetea, Mariana, et al.
Publicado: (2019)

Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones
por: Spetea, Mariana, et al.
Publicado: (2021)

Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists
por: Dumitrascuta, Maria, et al.
Publicado: (2017)

Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands
por: Sturaro, Chiara, et al.
Publicado: (2022)

Interactions of peripheral and central μ opioid systems during emotional stress
por: Bashkatova, Valentina, et al.
Publicado: (2010)

Spinal interaction between μ and δ opioid receptors in naive and morphine-tolerant rats
por: Riba, Pál, et al.
Publicado: (2009)

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II
por: Van Rijn, Richard M., et al.
Publicado: (2022)

Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain
por: Schmidhammer, Helmut, et al.
Publicado: (2023)

Synthesis, Biological, and Structural Explorations of New Zwitterionic Derivatives of 14-O-Methyloxymorphone, as Potent μ/δ Opioid Agonists and Peripherally Selective Antinociceptives
por: Spetea, Mariana, et al.
Publicado: (2018)

Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands
por: Schaller, David, et al.
Publicado: (2019)

Antinociceptive Efficacy of the µ-Opioid/Nociceptin Peptide-Based Hybrid KGNOP1 in Inflammatory Pain without Rewarding Effects in Mice: An Experimental Assessment and Molecular Docking
por: Dumitrascuta, Maria, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7nnnnaj14n3bp30jdg2vf18u1s