Cargando…
A Human TREK-1/HEK Cell Line: A Highly Efficient Screening Tool for Drug Development in Neurological Diseases
TREK-1 potassium channels are involved in a number of physiopathological processes such as neuroprotection, pain and depression. Molecules able to open or to block these channels can be clinically important. Having a cell model for screening such molecules is of particular interest. Here, we describ...
Autores principales: | Moha ou Maati, Hamid, Peyronnet, Rémi, Devader, Christelle, Veyssiere, Julie, Labbal, Fabien, Gandin, Carine, Mazella, Jean, Heurteaux, Catherine, Borsotto, Marc |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3194802/ https://www.ncbi.nlm.nih.gov/pubmed/22022421 http://dx.doi.org/10.1371/journal.pone.0025602 |
Ejemplares similares
-
Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin
por: Hivelin, Céline, et al.
Publicado: (2016) -
Retroinverso analogs of spadin display increased antidepressant effects
por: Veyssiere, Julie, et al.
Publicado: (2014) -
Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior
por: Moreno, Sébastien, et al.
Publicado: (2018) -
Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
por: Djillani, Alaeddine, et al.
Publicado: (2019) -
The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1
por: Mazella, Jean, et al.
Publicado: (2019)