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Structural studies of the PARP-1 BRCT domain

BACKGROUND: Poly(ADP-ribose) polymerase-1 (PARP-1) is one of the first proteins localized to foci of DNA damage. Upon activation by encountering nicked DNA, the PARP-1 mediated trans-poly(ADP-ribosyl)ation of DNA binding proteins occurs, facilitating access and accumulation of DNA repair factors. PA...

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Detalles Bibliográficos
Autores principales:	Loeffler, Paul A, Cuneo, Matthew J, Mueller, Geoffrey A, DeRose, Eugene F, Gabel, Scott A, London, Robert E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195086/ https://www.ncbi.nlm.nih.gov/pubmed/21967661 http://dx.doi.org/10.1186/1472-6807-11-37

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