Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea

Tetrabenazine (TBZ) is widely used to treat hyperkinetic movement disorders in adults; however, published experience with the drug in children is limited. Common side effects of TBZ include drowsiness, sedation, weakness, Parkinsonism, depression, and acute akathisia, all of which are reversible wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Zaki, Syed Ahmed, Lad, Vijay, Shanbag, Preeti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195137/
https://www.ncbi.nlm.nih.gov/pubmed/22022010
http://dx.doi.org/10.4103/0253-7613.84982
_version_ 1782214075266105344
author Zaki, Syed Ahmed
Lad, Vijay
Shanbag, Preeti
author_facet Zaki, Syed Ahmed
Lad, Vijay
Shanbag, Preeti
author_sort Zaki, Syed Ahmed
collection PubMed
description Tetrabenazine (TBZ) is widely used to treat hyperkinetic movement disorders in adults; however, published experience with the drug in children is limited. Common side effects of TBZ include drowsiness, sedation, weakness, Parkinsonism, depression, and acute akathisia, all of which are reversible with decreased doses. We report here a 7-year-old girl with rheumatic chorea who developed acute akinesia of all four limbs and dysarthria due to TBZ therapy. Withdrawal of the drug led to rapid improvement within 18 hours.
format Online
Article
Text
id pubmed-3195137
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-31951372011-10-21 Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea Zaki, Syed Ahmed Lad, Vijay Shanbag, Preeti Indian J Pharmacol Drug Watch Tetrabenazine (TBZ) is widely used to treat hyperkinetic movement disorders in adults; however, published experience with the drug in children is limited. Common side effects of TBZ include drowsiness, sedation, weakness, Parkinsonism, depression, and acute akathisia, all of which are reversible with decreased doses. We report here a 7-year-old girl with rheumatic chorea who developed acute akinesia of all four limbs and dysarthria due to TBZ therapy. Withdrawal of the drug led to rapid improvement within 18 hours. Medknow Publications 2011 /pmc/articles/PMC3195137/ /pubmed/22022010 http://dx.doi.org/10.4103/0253-7613.84982 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Zaki, Syed Ahmed
Lad, Vijay
Shanbag, Preeti
Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
title Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
title_full Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
title_fullStr Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
title_full_unstemmed Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
title_short Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
title_sort quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195137/
https://www.ncbi.nlm.nih.gov/pubmed/22022010
http://dx.doi.org/10.4103/0253-7613.84982
work_keys_str_mv AT zakisyedahmed quadriparesisanddysarthriaduetotetrabenazinetherapyinachildwithrheumaticchorea
AT ladvijay quadriparesisanddysarthriaduetotetrabenazinetherapyinachildwithrheumaticchorea
AT shanbagpreeti quadriparesisanddysarthriaduetotetrabenazinetherapyinachildwithrheumaticchorea

Ejemplares similares