Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis

Piperacillin/tazobactam is a commonly prescribed antibiotic and is generally considered safe. We report a case of a 2-year-old girl who developed hypokalemic metabolic alkalosis and bradycardia after receiving intravenous piperacillin-tazobactam for bronchopneumonia. Upon withdrawal of the drug, ser...

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Autores principales: Zaki, Syed Ahmed, Lad, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Drug Watch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195141/
https://www.ncbi.nlm.nih.gov/pubmed/22022014
http://dx.doi.org/10.4103/0253-7613.84986
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author Zaki, Syed Ahmed
Lad, Vijay
author_facet Zaki, Syed Ahmed
Lad, Vijay
author_sort Zaki, Syed Ahmed
collection PubMed
description Piperacillin/tazobactam is a commonly prescribed antibiotic and is generally considered safe. We report a case of a 2-year-old girl who developed hypokalemic metabolic alkalosis and bradycardia after receiving intravenous piperacillin-tazobactam for bronchopneumonia. Upon withdrawal of the drug, serum potassium normalized in 2 days. Hypokalemia is a serious adverse effect of piperacillin-tazobactam and should be suspected while treating patients with this drug. Early recognition and prompt withdrawal of the drug will result in lesser morbidity.
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spelling pubmed-31951412011-10-21 Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis Zaki, Syed Ahmed Lad, Vijay Indian J Pharmacol Drug Watch Piperacillin/tazobactam is a commonly prescribed antibiotic and is generally considered safe. We report a case of a 2-year-old girl who developed hypokalemic metabolic alkalosis and bradycardia after receiving intravenous piperacillin-tazobactam for bronchopneumonia. Upon withdrawal of the drug, serum potassium normalized in 2 days. Hypokalemia is a serious adverse effect of piperacillin-tazobactam and should be suspected while treating patients with this drug. Early recognition and prompt withdrawal of the drug will result in lesser morbidity. Medknow Publications 2011 /pmc/articles/PMC3195141/ /pubmed/22022014 http://dx.doi.org/10.4103/0253-7613.84986 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Drug Watch
Zaki, Syed Ahmed
Lad, Vijay
Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
title Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
title_full Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
title_fullStr Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
title_full_unstemmed Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
title_short Piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
title_sort piperacillin-tazobactam-induced hypokalemia and metabolic alkalosis
topic Drug Watch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195141/
https://www.ncbi.nlm.nih.gov/pubmed/22022014
http://dx.doi.org/10.4103/0253-7613.84986
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