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Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity
INTRODUCTION: While central nervous system serotonin has been implicated in a variety of problematic impulsive behaviors, biological manipulation of brain serotonin using acute tryptophan depletion for studying changes in impulsive behavior has received little attention. METHODS: Using identical tre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195237/ https://www.ncbi.nlm.nih.gov/pubmed/22084592 |
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author | Dougherty, Donald M. Richard, Dawn M. James, Lisa M. Mathias, Charles W. |
author_facet | Dougherty, Donald M. Richard, Dawn M. James, Lisa M. Mathias, Charles W. |
author_sort | Dougherty, Donald M. |
collection | PubMed |
description | INTRODUCTION: While central nervous system serotonin has been implicated in a variety of problematic impulsive behaviors, biological manipulation of brain serotonin using acute tryptophan depletion for studying changes in impulsive behavior has received little attention. METHODS: Using identical treatment conditions, we examined the effects of reduced serotonin synthesis for each of three matched groups using acute tryptophan depletion. Thirty healthy men and women (ages 18–45) were assigned to perform one of three tasks assessing different types of behavioral impulsivity: response initiation, response inhibition, and consequence sensitivity (N = 90). Participants completed two experimental days during which each consumed either a tryptophan-depletion or balanced-placebo amino-acid formulation and completed 5 sessions of their respective tasks at 0.25 h before and 1.5, 4.0, 5.0, and 6.0 h after beverage consumption. RESULTS: During peak effectiveness (5.0 h to 6.0 h following amino-acid consumption), depletion produced selective differences dependent on the type of impulsivity being tested. Specifically, relative to baseline testing (pre-depletion), response initiation impulsivity was significantly increased during the peak effects of depletion. And, when compared to placebo control, both response initiation and consequence sensitivity impulsivity were increased during the peak effects of depletion. CONCLUSION: Though response initiation and consequence sensitivity impulsivity were affected by tryptophan depletion, response inhibition impulsivity was not, suggesting that other biological processes may underlie this specific component of impulsivity. Future research in other populations or using different pharmacological agents is warranted to further examine the biological processes underlying these components of impulsivity. |
format | Online Article Text |
id | pubmed-3195237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-31952372011-11-14 Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity Dougherty, Donald M. Richard, Dawn M. James, Lisa M. Mathias, Charles W. Int J Tryptophan Res Original Research – Special Issue INTRODUCTION: While central nervous system serotonin has been implicated in a variety of problematic impulsive behaviors, biological manipulation of brain serotonin using acute tryptophan depletion for studying changes in impulsive behavior has received little attention. METHODS: Using identical treatment conditions, we examined the effects of reduced serotonin synthesis for each of three matched groups using acute tryptophan depletion. Thirty healthy men and women (ages 18–45) were assigned to perform one of three tasks assessing different types of behavioral impulsivity: response initiation, response inhibition, and consequence sensitivity (N = 90). Participants completed two experimental days during which each consumed either a tryptophan-depletion or balanced-placebo amino-acid formulation and completed 5 sessions of their respective tasks at 0.25 h before and 1.5, 4.0, 5.0, and 6.0 h after beverage consumption. RESULTS: During peak effectiveness (5.0 h to 6.0 h following amino-acid consumption), depletion produced selective differences dependent on the type of impulsivity being tested. Specifically, relative to baseline testing (pre-depletion), response initiation impulsivity was significantly increased during the peak effects of depletion. And, when compared to placebo control, both response initiation and consequence sensitivity impulsivity were increased during the peak effects of depletion. CONCLUSION: Though response initiation and consequence sensitivity impulsivity were affected by tryptophan depletion, response inhibition impulsivity was not, suggesting that other biological processes may underlie this specific component of impulsivity. Future research in other populations or using different pharmacological agents is warranted to further examine the biological processes underlying these components of impulsivity. Libertas Academica 2010-06-10 /pmc/articles/PMC3195237/ /pubmed/22084592 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. |
spellingShingle | Original Research – Special Issue Dougherty, Donald M. Richard, Dawn M. James, Lisa M. Mathias, Charles W. Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity |
title | Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity |
title_full | Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity |
title_fullStr | Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity |
title_full_unstemmed | Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity |
title_short | Effects of Acute Tryptophan Depletion on Three Different Types of Behavioral Impulsivity |
title_sort | effects of acute tryptophan depletion on three different types of behavioral impulsivity |
topic | Original Research – Special Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195237/ https://www.ncbi.nlm.nih.gov/pubmed/22084592 |
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