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Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories

Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE) in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers includin...

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Autores principales: Der Sahakian, G., Claessens, Y. E., Allo, J. C., Kansao, J., Kierzek, G., Pourriat, J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195346/
https://www.ncbi.nlm.nih.gov/pubmed/22046531
http://dx.doi.org/10.1155/2010/185453
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author Der Sahakian, G.
Claessens, Y. E.
Allo, J. C.
Kansao, J.
Kierzek, G.
Pourriat, J. L.
author_facet Der Sahakian, G.
Claessens, Y. E.
Allo, J. C.
Kansao, J.
Kierzek, G.
Pourriat, J. L.
author_sort Der Sahakian, G.
collection PubMed
description Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE) in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers including an increase in D-dimers levels, we investigated whether D-dimers could reliably rule out VTE across age categories. Method. We prospectively assessed the test performance in 1,004 patients visiting the emergency department during the 6-month period with low or intermediate risk of VTE who also received additional diagnostic procedures. Results. 67 patients had VTE with D-dimers levels above the threshold, and 3 patients displayed D-dimers levels below the threshold. We observed that specificity of D-dimers test decreased in an age-dependent manner. However, sensitivity and negative predictive value remained at very high level in each age category including older patients. Conclusion. We conclude that, even though D-dimers level could provide numerous false positive results in elderly patients, its high sensitivity could reliably help physicians to exclude the diagnosis of VTE in every low- and intermediate-risk patient.
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spelling pubmed-31953462011-11-01 Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories Der Sahakian, G. Claessens, Y. E. Allo, J. C. Kansao, J. Kierzek, G. Pourriat, J. L. Emerg Med Int Clinical Study Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE) in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers including an increase in D-dimers levels, we investigated whether D-dimers could reliably rule out VTE across age categories. Method. We prospectively assessed the test performance in 1,004 patients visiting the emergency department during the 6-month period with low or intermediate risk of VTE who also received additional diagnostic procedures. Results. 67 patients had VTE with D-dimers levels above the threshold, and 3 patients displayed D-dimers levels below the threshold. We observed that specificity of D-dimers test decreased in an age-dependent manner. However, sensitivity and negative predictive value remained at very high level in each age category including older patients. Conclusion. We conclude that, even though D-dimers level could provide numerous false positive results in elderly patients, its high sensitivity could reliably help physicians to exclude the diagnosis of VTE in every low- and intermediate-risk patient. Hindawi Publishing Corporation 2010 2010-07-27 /pmc/articles/PMC3195346/ /pubmed/22046531 http://dx.doi.org/10.1155/2010/185453 Text en Copyright © 2010 G. Der Sahakian et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Der Sahakian, G.
Claessens, Y. E.
Allo, J. C.
Kansao, J.
Kierzek, G.
Pourriat, J. L.
Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
title Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
title_full Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
title_fullStr Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
title_full_unstemmed Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
title_short Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
title_sort accuracy of d-dimers to rule out venous thromboembolism events across age categories
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195346/
https://www.ncbi.nlm.nih.gov/pubmed/22046531
http://dx.doi.org/10.1155/2010/185453
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