Cargando…
Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories
Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE) in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers includin...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195346/ https://www.ncbi.nlm.nih.gov/pubmed/22046531 http://dx.doi.org/10.1155/2010/185453 |
_version_ | 1782214119113359360 |
---|---|
author | Der Sahakian, G. Claessens, Y. E. Allo, J. C. Kansao, J. Kierzek, G. Pourriat, J. L. |
author_facet | Der Sahakian, G. Claessens, Y. E. Allo, J. C. Kansao, J. Kierzek, G. Pourriat, J. L. |
author_sort | Der Sahakian, G. |
collection | PubMed |
description | Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE) in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers including an increase in D-dimers levels, we investigated whether D-dimers could reliably rule out VTE across age categories. Method. We prospectively assessed the test performance in 1,004 patients visiting the emergency department during the 6-month period with low or intermediate risk of VTE who also received additional diagnostic procedures. Results. 67 patients had VTE with D-dimers levels above the threshold, and 3 patients displayed D-dimers levels below the threshold. We observed that specificity of D-dimers test decreased in an age-dependent manner. However, sensitivity and negative predictive value remained at very high level in each age category including older patients. Conclusion. We conclude that, even though D-dimers level could provide numerous false positive results in elderly patients, its high sensitivity could reliably help physicians to exclude the diagnosis of VTE in every low- and intermediate-risk patient. |
format | Online Article Text |
id | pubmed-3195346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31953462011-11-01 Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories Der Sahakian, G. Claessens, Y. E. Allo, J. C. Kansao, J. Kierzek, G. Pourriat, J. L. Emerg Med Int Clinical Study Background. Strategies combining pretest clinical assessment and D-dimers measurement efficiently and safely rule out venous thromboembolism events (VTE) in low- and intermediate-risk patients. Objectives. As process of ageing is associated with altered concentrations of coagulation markers including an increase in D-dimers levels, we investigated whether D-dimers could reliably rule out VTE across age categories. Method. We prospectively assessed the test performance in 1,004 patients visiting the emergency department during the 6-month period with low or intermediate risk of VTE who also received additional diagnostic procedures. Results. 67 patients had VTE with D-dimers levels above the threshold, and 3 patients displayed D-dimers levels below the threshold. We observed that specificity of D-dimers test decreased in an age-dependent manner. However, sensitivity and negative predictive value remained at very high level in each age category including older patients. Conclusion. We conclude that, even though D-dimers level could provide numerous false positive results in elderly patients, its high sensitivity could reliably help physicians to exclude the diagnosis of VTE in every low- and intermediate-risk patient. Hindawi Publishing Corporation 2010 2010-07-27 /pmc/articles/PMC3195346/ /pubmed/22046531 http://dx.doi.org/10.1155/2010/185453 Text en Copyright © 2010 G. Der Sahakian et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Der Sahakian, G. Claessens, Y. E. Allo, J. C. Kansao, J. Kierzek, G. Pourriat, J. L. Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories |
title | Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories |
title_full | Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories |
title_fullStr | Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories |
title_full_unstemmed | Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories |
title_short | Accuracy of D-Dimers to Rule Out Venous Thromboembolism Events across Age Categories |
title_sort | accuracy of d-dimers to rule out venous thromboembolism events across age categories |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195346/ https://www.ncbi.nlm.nih.gov/pubmed/22046531 http://dx.doi.org/10.1155/2010/185453 |
work_keys_str_mv | AT dersahakiang accuracyofddimerstoruleoutvenousthromboembolismeventsacrossagecategories AT claessensye accuracyofddimerstoruleoutvenousthromboembolismeventsacrossagecategories AT allojc accuracyofddimerstoruleoutvenousthromboembolismeventsacrossagecategories AT kansaoj accuracyofddimerstoruleoutvenousthromboembolismeventsacrossagecategories AT kierzekg accuracyofddimerstoruleoutvenousthromboembolismeventsacrossagecategories AT pourriatjl accuracyofddimerstoruleoutvenousthromboembolismeventsacrossagecategories |