Male infertility-linked point mutation disrupts the Ca(2+) oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCζ

A male infertility-linked human PLCζ (phospholipase Cζ) mutation introduced into mouse PLCζ completely abolishes both in vitro PIP(2) (phosphatidylinositol 4,5-bisphosphate) hydrolysis activity and the ability to trigger in vivo Ca(2+) oscillations in mouse eggs. Wild-type PLCζ initiated a normal pa...

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Detalles Bibliográficos
Autores principales: Nomikos, Michail, Elgmati, Khalil, Theodoridou, Maria, Calver, Brian L., Cumbes, Bevan, Nounesis, Georg, Swann, Karl, Lai, F. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2011
Materias:
Accelerated Publication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195387/
https://www.ncbi.nlm.nih.gov/pubmed/21204786
http://dx.doi.org/10.1042/BJ20101772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195387/
https://www.ncbi.nlm.nih.gov/pubmed/21204786
http://dx.doi.org/10.1042/BJ20101772

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