Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

BACKGROUND: Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers. Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we...

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Detalles Bibliográficos
Autores principales: Brenneis, Christian, Sisignano, Marco, Coste, Ovidiu, Altenrath, Kai, Fischer, Michael J, Angioni, Carlo, Fleming, Ingrid, Brandes, Ralf P, Reeh, Peter W, Woolf, Clifford J, Geisslinger, Gerd, Scholich, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195722/
https://www.ncbi.nlm.nih.gov/pubmed/21970373
http://dx.doi.org/10.1186/1744-8069-7-78

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