Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis

We evaluated the prognostic significance of lymph node ratio (LNR), number of metastatic lymph nodes divided by number of removed nodes in 924 breast carcinoma patients with 1–3 metastatic axillary lymph node(s). The most significant LNR threshold value separating patients in low- and high-risk grou...

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Autores principales: Duraker, Nüvit, Batı, Bakır, Demir, Davut, Çaynak, Zeynep Civelek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195782/
https://www.ncbi.nlm.nih.gov/pubmed/22091427
http://dx.doi.org/10.5402/2011/645450
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author Duraker, Nüvit
Batı, Bakır
Demir, Davut
Çaynak, Zeynep Civelek
author_facet Duraker, Nüvit
Batı, Bakır
Demir, Davut
Çaynak, Zeynep Civelek
author_sort Duraker, Nüvit
collection PubMed
description We evaluated the prognostic significance of lymph node ratio (LNR), number of metastatic lymph nodes divided by number of removed nodes in 924 breast carcinoma patients with 1–3 metastatic axillary lymph node(s). The most significant LNR threshold value separating patients in low- and high-risk groups with significant survival difference was 0.20 for disease-free survival (P < 0.001), 0.30 for locoregional recurrence-free survival (P < 0.001), and 0.15 for distant metastasis-free survival (P < 0.001), and the patients with lower LNR had better survival. All three LNR threshold values had independent prognostic significance in Cox analysis (P < 0.001 for all three of them). In conclusion, LNR is a useful tool in separating breast carcinoma patients with 1–3 metastatic lymph node(s) into low- and high-risk prognostic groups.
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spelling pubmed-31957822011-11-16 Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis Duraker, Nüvit Batı, Bakır Demir, Davut Çaynak, Zeynep Civelek ISRN Oncol Clinical Study We evaluated the prognostic significance of lymph node ratio (LNR), number of metastatic lymph nodes divided by number of removed nodes in 924 breast carcinoma patients with 1–3 metastatic axillary lymph node(s). The most significant LNR threshold value separating patients in low- and high-risk groups with significant survival difference was 0.20 for disease-free survival (P < 0.001), 0.30 for locoregional recurrence-free survival (P < 0.001), and 0.15 for distant metastasis-free survival (P < 0.001), and the patients with lower LNR had better survival. All three LNR threshold values had independent prognostic significance in Cox analysis (P < 0.001 for all three of them). In conclusion, LNR is a useful tool in separating breast carcinoma patients with 1–3 metastatic lymph node(s) into low- and high-risk prognostic groups. International Scholarly Research Network 2011 2011-10-12 /pmc/articles/PMC3195782/ /pubmed/22091427 http://dx.doi.org/10.5402/2011/645450 Text en Copyright © 2011 Nüvit Duraker et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Duraker, Nüvit
Batı, Bakır
Demir, Davut
Çaynak, Zeynep Civelek
Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis
title Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis
title_full Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis
title_fullStr Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis
title_full_unstemmed Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis
title_short Prognostic Significance of the Number of Removed and Metastatic Lymph Nodes and Lymph Node Ratio in Breast Carcinoma Patients with 1–3 Axillary Lymph Node(s) Metastasis
title_sort prognostic significance of the number of removed and metastatic lymph nodes and lymph node ratio in breast carcinoma patients with 1–3 axillary lymph node(s) metastasis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195782/
https://www.ncbi.nlm.nih.gov/pubmed/22091427
http://dx.doi.org/10.5402/2011/645450
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AT demirdavut prognosticsignificanceofthenumberofremovedandmetastaticlymphnodesandlymphnoderatioinbreastcarcinomapatientswith13axillarylymphnodesmetastasis
AT caynakzeynepcivelek prognosticsignificanceofthenumberofremovedandmetastaticlymphnodesandlymphnoderatioinbreastcarcinomapatientswith13axillarylymphnodesmetastasis

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