Proapoptotic role of nuclear clusterin in brain

Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous rep...

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Detalles Bibliográficos
Autores principales: Kim, Nayoung, Choi, Wan Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association of Anatomists 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195820/
https://www.ncbi.nlm.nih.gov/pubmed/22025968
http://dx.doi.org/10.5115/acb.2011.44.3.169
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author Kim, Nayoung
Choi, Wan Sung
author_facet Kim, Nayoung
Choi, Wan Sung
author_sort Kim, Nayoung
collection PubMed
description Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration.
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spelling pubmed-31958202011-10-24 Proapoptotic role of nuclear clusterin in brain Kim, Nayoung Choi, Wan Sung Anat Cell Biol Review Article Clusterin (CLU) is a multifunctional glycoprotein that has secretory and nuclear isoforms. The two isoforms are known to play opposite roles in cell survival/death. In this review, we summarize recent progress on the pro-apoptotic function of nuclear CLU in vitro and in vivo and discuss previous reports on the role of CLU in brain damage and neurodegeneration. Korean Association of Anatomists 2011-09 2011-09-29 /pmc/articles/PMC3195820/ /pubmed/22025968 http://dx.doi.org/10.5115/acb.2011.44.3.169 Text en Copyright © 2011. Anatomy & Cell Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Nayoung
Choi, Wan Sung
Proapoptotic role of nuclear clusterin in brain
title Proapoptotic role of nuclear clusterin in brain
title_full Proapoptotic role of nuclear clusterin in brain
title_fullStr Proapoptotic role of nuclear clusterin in brain
title_full_unstemmed Proapoptotic role of nuclear clusterin in brain
title_short Proapoptotic role of nuclear clusterin in brain
title_sort proapoptotic role of nuclear clusterin in brain
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195820/
https://www.ncbi.nlm.nih.gov/pubmed/22025968
http://dx.doi.org/10.5115/acb.2011.44.3.169
work_keys_str_mv AT kimnayoung proapoptoticroleofnuclearclusterininbrain
AT choiwansung proapoptoticroleofnuclearclusterininbrain

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