Cargando…
Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
This paper addresses the role of paracetamol in placebo-controlled osteoarthritis (OA) trials and the potential contribution to the large placebo response in such trials. Paracetamol is used as rescue medication in nearly all OA placebo-controlled trials. Triggered by the discussion about the placeb...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195867/ https://www.ncbi.nlm.nih.gov/pubmed/22110930 http://dx.doi.org/10.1155/2011/696791 |
_version_ | 1782214175167086592 |
---|---|
author | Zeidler, Henning |
author_facet | Zeidler, Henning |
author_sort | Zeidler, Henning |
collection | PubMed |
description | This paper addresses the role of paracetamol in placebo-controlled osteoarthritis (OA) trials and the potential contribution to the large placebo response in such trials. Paracetamol is used as rescue medication in nearly all OA placebo-controlled trials. Triggered by the discussion about the placebo effect in general and because of the lack of systematic reviews of placebo effect in OA trials, a recent meta-analysis examined the placebo effect and its potential determinants in the treatment of OA, as the main result came out that placebo is very effective in the treatment of OA, especially for pain, stiffness, and self-reported function. However, mostly limited data are available from published OA trials on the starting dose, final dose, dose over time of paracetamol use, and the percentage of patients who used rescue medication during the study. Paracetamol may be an important additional simulated effect of placebo administration mimicking the true placebo effect and thus a missing link contributing partially to the large placebo response in OA trials. Therefore, the positive effect of paracetamol on symptom relief as well as the need for standardized recording of rescue medication should be taken into account when designing, executing, and interpreting placebo-controlled OA studies. |
format | Online Article Text |
id | pubmed-3195867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31958672011-11-22 Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? Zeidler, Henning Pain Res Treat Review Article This paper addresses the role of paracetamol in placebo-controlled osteoarthritis (OA) trials and the potential contribution to the large placebo response in such trials. Paracetamol is used as rescue medication in nearly all OA placebo-controlled trials. Triggered by the discussion about the placebo effect in general and because of the lack of systematic reviews of placebo effect in OA trials, a recent meta-analysis examined the placebo effect and its potential determinants in the treatment of OA, as the main result came out that placebo is very effective in the treatment of OA, especially for pain, stiffness, and self-reported function. However, mostly limited data are available from published OA trials on the starting dose, final dose, dose over time of paracetamol use, and the percentage of patients who used rescue medication during the study. Paracetamol may be an important additional simulated effect of placebo administration mimicking the true placebo effect and thus a missing link contributing partially to the large placebo response in OA trials. Therefore, the positive effect of paracetamol on symptom relief as well as the need for standardized recording of rescue medication should be taken into account when designing, executing, and interpreting placebo-controlled OA studies. Hindawi Publishing Corporation 2011 2011-06-06 /pmc/articles/PMC3195867/ /pubmed/22110930 http://dx.doi.org/10.1155/2011/696791 Text en Copyright © 2011 Henning Zeidler. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zeidler, Henning Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? |
title | Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? |
title_full | Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? |
title_fullStr | Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? |
title_full_unstemmed | Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? |
title_short | Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? |
title_sort | paracetamol and the placebo effect in osteoarthritis trials: a missing link? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195867/ https://www.ncbi.nlm.nih.gov/pubmed/22110930 http://dx.doi.org/10.1155/2011/696791 |
work_keys_str_mv | AT zeidlerhenning paracetamolandtheplaceboeffectinosteoarthritistrialsamissinglink |