Cargando…

Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?

This paper addresses the role of paracetamol in placebo-controlled osteoarthritis (OA) trials and the potential contribution to the large placebo response in such trials. Paracetamol is used as rescue medication in nearly all OA placebo-controlled trials. Triggered by the discussion about the placeb...

Descripción completa

Detalles Bibliográficos
Autor principal: Zeidler, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195867/
https://www.ncbi.nlm.nih.gov/pubmed/22110930
http://dx.doi.org/10.1155/2011/696791
_version_ 1782214175167086592
author Zeidler, Henning
author_facet Zeidler, Henning
author_sort Zeidler, Henning
collection PubMed
description This paper addresses the role of paracetamol in placebo-controlled osteoarthritis (OA) trials and the potential contribution to the large placebo response in such trials. Paracetamol is used as rescue medication in nearly all OA placebo-controlled trials. Triggered by the discussion about the placebo effect in general and because of the lack of systematic reviews of placebo effect in OA trials, a recent meta-analysis examined the placebo effect and its potential determinants in the treatment of OA, as the main result came out that placebo is very effective in the treatment of OA, especially for pain, stiffness, and self-reported function. However, mostly limited data are available from published OA trials on the starting dose, final dose, dose over time of paracetamol use, and the percentage of patients who used rescue medication during the study. Paracetamol may be an important additional simulated effect of placebo administration mimicking the true placebo effect and thus a missing link contributing partially to the large placebo response in OA trials. Therefore, the positive effect of paracetamol on symptom relief as well as the need for standardized recording of rescue medication should be taken into account when designing, executing, and interpreting placebo-controlled OA studies.
format Online
Article
Text
id pubmed-3195867
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-31958672011-11-22 Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link? Zeidler, Henning Pain Res Treat Review Article This paper addresses the role of paracetamol in placebo-controlled osteoarthritis (OA) trials and the potential contribution to the large placebo response in such trials. Paracetamol is used as rescue medication in nearly all OA placebo-controlled trials. Triggered by the discussion about the placebo effect in general and because of the lack of systematic reviews of placebo effect in OA trials, a recent meta-analysis examined the placebo effect and its potential determinants in the treatment of OA, as the main result came out that placebo is very effective in the treatment of OA, especially for pain, stiffness, and self-reported function. However, mostly limited data are available from published OA trials on the starting dose, final dose, dose over time of paracetamol use, and the percentage of patients who used rescue medication during the study. Paracetamol may be an important additional simulated effect of placebo administration mimicking the true placebo effect and thus a missing link contributing partially to the large placebo response in OA trials. Therefore, the positive effect of paracetamol on symptom relief as well as the need for standardized recording of rescue medication should be taken into account when designing, executing, and interpreting placebo-controlled OA studies. Hindawi Publishing Corporation 2011 2011-06-06 /pmc/articles/PMC3195867/ /pubmed/22110930 http://dx.doi.org/10.1155/2011/696791 Text en Copyright © 2011 Henning Zeidler. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zeidler, Henning
Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
title Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
title_full Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
title_fullStr Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
title_full_unstemmed Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
title_short Paracetamol and the Placebo Effect in Osteoarthritis Trials: A Missing Link?
title_sort paracetamol and the placebo effect in osteoarthritis trials: a missing link?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195867/
https://www.ncbi.nlm.nih.gov/pubmed/22110930
http://dx.doi.org/10.1155/2011/696791
work_keys_str_mv AT zeidlerhenning paracetamolandtheplaceboeffectinosteoarthritistrialsamissinglink