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The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles

The spatial relationship between mitochondria and the membrane systems, more specifically the calcium release units (CRUs) of skeletal muscle, is of profound functional significance. CRUs are the sites at which Ca(2+) is released from the sarcoplasmic reticulum during muscle activation. Close mitoch...

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Detalles Bibliográficos
Autores principales: Franzini-Armstrong, Clara, Boncompagni, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196067/
https://www.ncbi.nlm.nih.gov/pubmed/22013386
http://dx.doi.org/10.1155/2011/830573
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author Franzini-Armstrong, Clara
Boncompagni, Simona
author_facet Franzini-Armstrong, Clara
Boncompagni, Simona
author_sort Franzini-Armstrong, Clara
collection PubMed
description The spatial relationship between mitochondria and the membrane systems, more specifically the calcium release units (CRUs) of skeletal muscle, is of profound functional significance. CRUs are the sites at which Ca(2+) is released from the sarcoplasmic reticulum during muscle activation. Close mitochondrion-CRU proximity allows the organelles to take up Ca(2+) and thus stimulate aerobic metabolism. Skeletal muscles of most mammals display an extensive, developmentally regulated, close mitochondrion-CRU association, fostered by tethering links between the organelles. A comparative look at the vertebrate subphylum however shows that this specific association is only present in the higher vertebrates (mammals). Muscles in all other vertebrates, even if capable of fast activity, rely on a less precise and more limited mitochondrion-CRU proximity, despite some tethering connections. This is most evident in fish muscles. Clustering of free subsarcolemmal mitochondria in proximity of capillaries is also more frequently achieved in mammalian than in other vertebrates.
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spelling pubmed-31960672011-10-19 The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles Franzini-Armstrong, Clara Boncompagni, Simona J Biomed Biotechnol Review Article The spatial relationship between mitochondria and the membrane systems, more specifically the calcium release units (CRUs) of skeletal muscle, is of profound functional significance. CRUs are the sites at which Ca(2+) is released from the sarcoplasmic reticulum during muscle activation. Close mitochondrion-CRU proximity allows the organelles to take up Ca(2+) and thus stimulate aerobic metabolism. Skeletal muscles of most mammals display an extensive, developmentally regulated, close mitochondrion-CRU association, fostered by tethering links between the organelles. A comparative look at the vertebrate subphylum however shows that this specific association is only present in the higher vertebrates (mammals). Muscles in all other vertebrates, even if capable of fast activity, rely on a less precise and more limited mitochondrion-CRU proximity, despite some tethering connections. This is most evident in fish muscles. Clustering of free subsarcolemmal mitochondria in proximity of capillaries is also more frequently achieved in mammalian than in other vertebrates. Hindawi Publishing Corporation 2011 2011-10-13 /pmc/articles/PMC3196067/ /pubmed/22013386 http://dx.doi.org/10.1155/2011/830573 Text en Copyright © 2011 C. Franzini-Armstrong and S. Boncompagni. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Franzini-Armstrong, Clara
Boncompagni, Simona
The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
title The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
title_full The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
title_fullStr The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
title_full_unstemmed The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
title_short The Evolution of the Mitochondria-to-Calcium Release Units Relationship in Vertebrate Skeletal Muscles
title_sort evolution of the mitochondria-to-calcium release units relationship in vertebrate skeletal muscles
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196067/
https://www.ncbi.nlm.nih.gov/pubmed/22013386
http://dx.doi.org/10.1155/2011/830573
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