Cargando…

Identification of Human Fumarylacetoacetate Hydrolase Domain-containing Protein 1 (FAHD1) as a Novel Mitochondrial Acylpyruvase

The human fumarylacetoacetate hydrolase (FAH) domain-containing protein 1 (FAHD1) is part of the FAH protein superfamily, but its enzymatic function is unknown. In the quest for a putative enzymatic function of FAHD1, we found that FAHD1 exhibits acylpyruvase activity, demonstrated by the hydrolysis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pircher, Haymo, Straganz, Grit D., Ehehalt, Daniela, Morrow, Geneviève, Tanguay, Robert M., Jansen-Dürr, Pidder
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196145/ https://www.ncbi.nlm.nih.gov/pubmed/21878618 http://dx.doi.org/10.1074/jbc.M111.264770

Ejemplares similares

Inhibitors of Fumarylacetoacetate Hydrolase Domain Containing Protein 1 (FAHD1)
por: Weiss, Alexander K. H., et al.
Publicado: (2021)

FAH Domain Containing Protein 1 (FAHD-1) Is Required for Mitochondrial Function and Locomotion Activity in C. elegans
por: Taferner, Andrea, et al.
Publicado: (2015)

Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
por: Weiss, Alexander K. H., et al.
Publicado: (2019)

Structural and functional comparison of fumarylacetoacetate domain containing protein 1 in human and mouse
por: Weiss, Alexander K.H., et al.
Publicado: (2020)

The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan
por: Cuskin, Fiona, et al.
Publicado: (2015)

Modulation of serotonin signaling by the putative oxaloacetate decarboxylase FAHD-1 in Caenorhabditis elegans
por: Baraldo, Giorgia, et al.
Publicado: (2019)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
por: Waz, Shaimaa, et al.
Publicado: (2017)

Human Carboxymethylenebutenolidase as a Bioactivating Hydrolase of Olmesartan Medoxomil in Liver and Intestine
por: Ishizuka, Tomoko, et al.
Publicado: (2010)

Identification of Euglena gracilis β-1,3-glucan phosphorylase and establishment of a new glycoside hydrolase (GH) family GH149
por: Kuhaudomlarp, Sakonwan, et al.
Publicado: (2018)

Unraveling the subtleties of β-(1→3)-glucan phosphorylase specificity in the GH94, GH149, and GH161 glycoside hydrolase families
por: Kuhaudomlarp, Sakonwan, et al.
Publicado: (2019)

AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis?
por: Gerna, Davide, et al.
Publicado: (2021)

Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44
por: Ariza, Antonio, et al.
Publicado: (2011)

Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)
por: Miazzi, Cristina, et al.
Publicado: (2014)

A subfamily roadmap of the evolutionarily diverse glycoside hydrolase family 16 (GH16)
por: Viborg, Alexander Holm, et al.
Publicado: (2019)

Structure and function of Bs164 β-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164
por: Armstrong, Zachary, et al.
Publicado: (2020)

Purification and characterization of native human insulin-like growth factor binding protein-6
por: Taferner, Andrea, et al.
Publicado: (2011)

Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1
por: Li, Li, et al.
Publicado: (2017)

High Glycolytic Activity Enhances Stem Cell Reprogramming of Fahd1-KO Mouse Embryonic Fibroblasts
por: Salti, Ahmad, et al.
Publicado: (2021)

PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase
por: Blazer, Levi L., et al.
Publicado: (2016)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Phenylalanine suppresses cell death caused by loss of fumarylacetoacetate hydrolase in Arabidopsis
por: Jiang, Yihe, et al.
Publicado: (2022)

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones
por: Longstaff, Colin, et al.
Publicado: (2013)

The Dimer Interface of the Membrane Type 1 Matrix Metalloproteinase Hemopexin Domain: CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTIONS
por: Tochowicz, Anna, et al.
Publicado: (2011)

Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N(4)-Ethenocytosine-containing DNA
por: Lingaraju, Gondichatnahalli M., et al.
Publicado: (2011)

A missense mutation (Q279R) in the Fumarylacetoacetate Hydrolase gene, responsible for hereditary tyrosinemia, acts as a splicing mutation
por: Dreumont, Natacha, et al.
Publicado: (2001)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
por: Yonesu, Kiyoaki, et al.
Publicado: (2011)

Domain architecture divergence leads to functional divergence in binding and catalytic domains of bacterial and fungal cellobiohydrolases
por: Nakamura, Akihiko, et al.
Publicado: (2020)

Roles of Phosphate Recognition in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase (IPK1) Substrate Binding and Activation
por: Gosein, Varin, et al.
Publicado: (2013)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
por: Seeliger, Jessica C., et al.
Publicado: (2012)

Insights into the Cnx1E catalyzed MPT-AMP hydrolysis
por: Hercher, Thomas W., et al.
Publicado: (2020)

Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase
por: Figiel, Małgorzata, et al.
Publicado: (2018)

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
por: Malcolm, Tess R., et al.
Publicado: (2021)

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase
por: Purser, Nicholas, et al.
Publicado: (2023)

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
por: Emberley, Ethan D., et al.
Publicado: (2012)

Dissecting the Metabolic Roles of Pteridine Reductase 1 in Trypanosoma brucei and Leishmania major
por: Ong, Han B., et al.
Publicado: (2011)

Fumarylacetoacetate hydrolase gene as a knockout target for hepatic chimerism and donor liver production
por: Larson, Ellen L., et al.
Publicado: (2021)

Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2
por: Trostchansky, Andrés, et al.
Publicado: (2011)

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
por: Dai, Han, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_m68i6c4g242mnum7tq0of78kk5