Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery

In trypanosomatids, glucose-6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentosephosphate pathway, is essential for the defense of the parasite against oxidative stress. Trypanosoma brucei, Trypanosoma cruzi, and Leishmania mexicana G6PDHs have been characterized. The parasites' G...

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Detalles Bibliográficos
Autores principales: Gupta, Shreedhara, Igoillo-Esteve, Mariana, Michels, Paul A. M., Cordeiro, Artur T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196259/
https://www.ncbi.nlm.nih.gov/pubmed/22091394
http://dx.doi.org/10.4061/2011/135701

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