Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells

The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased t...

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Autores principales: Ogita, Tasuku, Nakashima, Megumi, Morita, Hidetoshi, Saito, Yasuo, Suzuki, Takuya, Tanabe, Soichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196311/
https://www.ncbi.nlm.nih.gov/pubmed/22013382
http://dx.doi.org/10.1155/2011/378417
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author Ogita, Tasuku
Nakashima, Megumi
Morita, Hidetoshi
Saito, Yasuo
Suzuki, Takuya
Tanabe, Soichi
author_facet Ogita, Tasuku
Nakashima, Megumi
Morita, Hidetoshi
Saito, Yasuo
Suzuki, Takuya
Tanabe, Soichi
author_sort Ogita, Tasuku
collection PubMed
description The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease.
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spelling pubmed-31963112011-10-19 Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells Ogita, Tasuku Nakashima, Megumi Morita, Hidetoshi Saito, Yasuo Suzuki, Takuya Tanabe, Soichi J Biomed Biotechnol Research Article The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-β plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease. Hindawi Publishing Corporation 2011 2011-10-12 /pmc/articles/PMC3196311/ /pubmed/22013382 http://dx.doi.org/10.1155/2011/378417 Text en Copyright © 2011 Tasuku Ogita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ogita, Tasuku
Nakashima, Megumi
Morita, Hidetoshi
Saito, Yasuo
Suzuki, Takuya
Tanabe, Soichi
Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells
title Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells
title_full Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells
title_fullStr Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells
title_full_unstemmed Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells
title_short Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells
title_sort streptococcus thermophilus st28 ameliorates colitis in mice partially by suppression of inflammatory th17 cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196311/
https://www.ncbi.nlm.nih.gov/pubmed/22013382
http://dx.doi.org/10.1155/2011/378417
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