APOE Genotype-Function Relationship: Evidence of −491 A/T Promoter Polymorphism Modifying Transcription Control but Not Type 2 Diabetes Risk

BACKGROUND: The apolipoprotein E gene (APOE) coding polymorphism modifies the risks of Alzheimer's disease, type 2 diabetes, and coronary heart disease. Aside from the coding variants, single nucleotide polymorphism (SNP) of the APOE promoter has also been shown to modify the risk of Alzheimer&...

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Detalles Bibliográficos
Autores principales: Geng, Hua, Law, Peggy P. Y., Ng, Maggie C. Y., Li, Ting, Liang, Li-Yun, Ge, Tian-Fang, Wong, Kam-Bo, Liang, Chun, Ma, Ronald C., So, Wing-Yee, Chan, Juliana C. N., Ho, Yuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196492/
https://www.ncbi.nlm.nih.gov/pubmed/22028770
http://dx.doi.org/10.1371/journal.pone.0024669

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