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HLA-DRB1 May Be Antagonistically Regulated by the Coordinately Evolved Promoter and 3′-UTR under Stabilizing Selection

HLA-DRB1 is the most polymorphic MHC (major histocompatibility complex) class II gene in human, and plays a crucial role in the development and function of the immune system. Extensive polymorphisms exist in the promoter and 3′-UTR of HLA-DRB1, especially a LTR (Long terminal repeat) element in the...

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Detalles Bibliográficos
Autores principales:	Liu, Benrong, Fu, Yonggui, Wang, Zhifen, Zhou, Sisi, Sun, Yu, Wu, Yuping, Xu, Anlong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196528/ https://www.ncbi.nlm.nih.gov/pubmed/22028790 http://dx.doi.org/10.1371/journal.pone.0025794

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