Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome

Recent insight into the underlying molecular and cellular mechanisms of fragile X syndrome (FXS) has led to the proposal and development of new pharmaceutical treatment strategies, and the initiation of clinical trials aimed at correcting core symptoms of the developmental disorder. Consequently, th...

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Detalles Bibliográficos
Autores principales: Farzin, Faraz, Scaggs, Felicia, Hervey, Crystal, Berry-Kravis, Elizabeth, Hessl, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196645/
https://www.ncbi.nlm.nih.gov/pubmed/21267642
http://dx.doi.org/10.1007/s10803-011-1176-2
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author Farzin, Faraz
Scaggs, Felicia
Hervey, Crystal
Berry-Kravis, Elizabeth
Hessl, David
author_facet Farzin, Faraz
Scaggs, Felicia
Hervey, Crystal
Berry-Kravis, Elizabeth
Hessl, David
author_sort Farzin, Faraz
collection PubMed
description Recent insight into the underlying molecular and cellular mechanisms of fragile X syndrome (FXS) has led to the proposal and development of new pharmaceutical treatment strategies, and the initiation of clinical trials aimed at correcting core symptoms of the developmental disorder. Consequently, there is an urgent and critical need for outcome measures that are valid for quantifying specific symptoms of FXS and that are consistent across time. We used eye tracking to evaluate test–retest reliability of gaze and pupillometry measures in individuals with FXS and we demonstrate that these measures are viable options for assessing treatment-specific outcomes related to a core behavioral feature of the disorder.
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spelling pubmed-31966452011-11-07 Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome Farzin, Faraz Scaggs, Felicia Hervey, Crystal Berry-Kravis, Elizabeth Hessl, David J Autism Dev Disord Original Paper Recent insight into the underlying molecular and cellular mechanisms of fragile X syndrome (FXS) has led to the proposal and development of new pharmaceutical treatment strategies, and the initiation of clinical trials aimed at correcting core symptoms of the developmental disorder. Consequently, there is an urgent and critical need for outcome measures that are valid for quantifying specific symptoms of FXS and that are consistent across time. We used eye tracking to evaluate test–retest reliability of gaze and pupillometry measures in individuals with FXS and we demonstrate that these measures are viable options for assessing treatment-specific outcomes related to a core behavioral feature of the disorder. Springer US 2011-01-26 2011 /pmc/articles/PMC3196645/ /pubmed/21267642 http://dx.doi.org/10.1007/s10803-011-1176-2 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Paper
Farzin, Faraz
Scaggs, Felicia
Hervey, Crystal
Berry-Kravis, Elizabeth
Hessl, David
Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome
title Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome
title_full Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome
title_fullStr Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome
title_full_unstemmed Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome
title_short Reliability of Eye Tracking and Pupillometry Measures in Individuals with Fragile X Syndrome
title_sort reliability of eye tracking and pupillometry measures in individuals with fragile x syndrome
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196645/
https://www.ncbi.nlm.nih.gov/pubmed/21267642
http://dx.doi.org/10.1007/s10803-011-1176-2
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