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Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents
During the past decade, intravenous iron supplementation to ESA (erythropoiesis-stimulating agent) therapy has emerged as an option to augment hemoglobin response in anemic cancer patients. In this paper, the results of seven published randomized clinical trials assessing the role of iron supplement...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196863/ https://www.ncbi.nlm.nih.gov/pubmed/22111015 http://dx.doi.org/10.5402/2011/108397 |
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author | Karlsson, Torbjörn |
author_facet | Karlsson, Torbjörn |
author_sort | Karlsson, Torbjörn |
collection | PubMed |
description | During the past decade, intravenous iron supplementation to ESA (erythropoiesis-stimulating agent) therapy has emerged as an option to augment hemoglobin response in anemic cancer patients. In this paper, the results of seven published randomized clinical trials assessing the role of iron supplementation to ESA therapy in the hematology/oncology setting will be discussed. The pathogenetic mechanisms behind functional iron deficiency, a major reason for ESA hyporesponsiveness in cancer, will also be described. |
format | Online Article Text |
id | pubmed-3196863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-31968632011-11-22 Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents Karlsson, Torbjörn ISRN Hematol Review Article During the past decade, intravenous iron supplementation to ESA (erythropoiesis-stimulating agent) therapy has emerged as an option to augment hemoglobin response in anemic cancer patients. In this paper, the results of seven published randomized clinical trials assessing the role of iron supplementation to ESA therapy in the hematology/oncology setting will be discussed. The pathogenetic mechanisms behind functional iron deficiency, a major reason for ESA hyporesponsiveness in cancer, will also be described. International Scholarly Research Network 2011 2011-10-13 /pmc/articles/PMC3196863/ /pubmed/22111015 http://dx.doi.org/10.5402/2011/108397 Text en Copyright © 2011 Torbjörn Karlsson. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Karlsson, Torbjörn Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents |
title | Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents |
title_full | Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents |
title_fullStr | Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents |
title_full_unstemmed | Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents |
title_short | Effects of Iron Supplementation on Erythropoietic Response in Patients with Cancer-Associated Anemia Treated by Means of Erythropoietic Stimulating Agents |
title_sort | effects of iron supplementation on erythropoietic response in patients with cancer-associated anemia treated by means of erythropoietic stimulating agents |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196863/ https://www.ncbi.nlm.nih.gov/pubmed/22111015 http://dx.doi.org/10.5402/2011/108397 |
work_keys_str_mv | AT karlssontorbjorn effectsofironsupplementationonerythropoieticresponseinpatientswithcancerassociatedanemiatreatedbymeansoferythropoieticstimulatingagents |