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Novel Phenazine 5,10-Dioxides Release (•)OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo
Phenazine 5,10-dioxides (PDOs) are a new class of bioreductive cytotoxins, which could act towards tumours containing hypoxic regions. The PDOs selective-hypoxic bioreduction was probed in vitro; however, the mechanism of action has not been completely explained. Besides, PDOs in vivo antitumour act...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Scholarly Research Network
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196961/ https://www.ncbi.nlm.nih.gov/pubmed/22084710 http://dx.doi.org/10.5402/2011/314209 |