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The Role of Tobacco-Derived Carcinogens in Pancreas Cancer

The extremely poor outcome from pancreas cancer is well known. However, its aetiology less well appreciated, and the molecular mechanisms underlying this are poorly understood. Tobacco usage is one of the strongest risk factors for this disease, and this is a completely avoidable hazard. In addition...

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Autores principales: Lochan, Rajiv, Reeves, Helen L., Daly, Anne K., Charnley, Richard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196993/
https://www.ncbi.nlm.nih.gov/pubmed/22084727
http://dx.doi.org/10.5402/2011/249235
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author Lochan, Rajiv
Reeves, Helen L.
Daly, Anne K.
Charnley, Richard M.
author_facet Lochan, Rajiv
Reeves, Helen L.
Daly, Anne K.
Charnley, Richard M.
author_sort Lochan, Rajiv
collection PubMed
description The extremely poor outcome from pancreas cancer is well known. However, its aetiology less well appreciated, and the molecular mechanisms underlying this are poorly understood. Tobacco usage is one of the strongest risk factors for this disease, and this is a completely avoidable hazard. In addition, there are well described hereditary diseases which predispose, and familial pancreas cancer. We have sought here to summarise the role of tobacco-derived carcinogens and the mode of their tumorigenic action on the pancreas. There is compelling evidence from animal and human studies (laboratory including cell line studies and epidemiologic) that tobacco derived carcinogens cause pancreas cancer. However, the manner in which they do so is not entirely apparent. There is also compelling evidence that synergism with genetic and other life-style factors—like diet obesity—results in a multifactorial causation of the disease. Ascertaining the role of tobacco carcinogens in the development of this cancer and their interaction with other risk factors will enable novel therapeutic and preventative strategies to improve outcome from this appalling malignancy.
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spelling pubmed-31969932011-11-14 The Role of Tobacco-Derived Carcinogens in Pancreas Cancer Lochan, Rajiv Reeves, Helen L. Daly, Anne K. Charnley, Richard M. ISRN Oncol Review Article The extremely poor outcome from pancreas cancer is well known. However, its aetiology less well appreciated, and the molecular mechanisms underlying this are poorly understood. Tobacco usage is one of the strongest risk factors for this disease, and this is a completely avoidable hazard. In addition, there are well described hereditary diseases which predispose, and familial pancreas cancer. We have sought here to summarise the role of tobacco-derived carcinogens and the mode of their tumorigenic action on the pancreas. There is compelling evidence from animal and human studies (laboratory including cell line studies and epidemiologic) that tobacco derived carcinogens cause pancreas cancer. However, the manner in which they do so is not entirely apparent. There is also compelling evidence that synergism with genetic and other life-style factors—like diet obesity—results in a multifactorial causation of the disease. Ascertaining the role of tobacco carcinogens in the development of this cancer and their interaction with other risk factors will enable novel therapeutic and preventative strategies to improve outcome from this appalling malignancy. International Scholarly Research Network 2011 2011-07-17 /pmc/articles/PMC3196993/ /pubmed/22084727 http://dx.doi.org/10.5402/2011/249235 Text en Copyright © 2011 Rajiv Lochan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lochan, Rajiv
Reeves, Helen L.
Daly, Anne K.
Charnley, Richard M.
The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
title The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
title_full The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
title_fullStr The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
title_full_unstemmed The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
title_short The Role of Tobacco-Derived Carcinogens in Pancreas Cancer
title_sort role of tobacco-derived carcinogens in pancreas cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196993/
https://www.ncbi.nlm.nih.gov/pubmed/22084727
http://dx.doi.org/10.5402/2011/249235
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