Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?

We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of HbS in favor of HbF, possibly reducing the sever...

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Detalles Bibliográficos
Autores principales: Giordano, P. C., Huisman, W., Harteveld, C. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197074/
https://www.ncbi.nlm.nih.gov/pubmed/22084698
http://dx.doi.org/10.5402/2011/473152
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author Giordano, P. C.
Huisman, W.
Harteveld, C. L.
author_facet Giordano, P. C.
Huisman, W.
Harteveld, C. L.
author_sort Giordano, P. C.
collection PubMed
description We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of HbS in favor of HbF, possibly reducing the severity of the disease. We believe that it would be worthwhile to monitor the course of the disease comparing cases with identical genotypes with and without iron depletion, and we advise to consider chelation therapy to reduce iron overload in patients with SCD.
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spelling pubmed-31970742011-11-14 Iron Depletion: An Ameliorating Factor for Sickle Cell Disease? Giordano, P. C. Huisman, W. Harteveld, C. L. ISRN Hematol Case Report We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of HbS in favor of HbF, possibly reducing the severity of the disease. We believe that it would be worthwhile to monitor the course of the disease comparing cases with identical genotypes with and without iron depletion, and we advise to consider chelation therapy to reduce iron overload in patients with SCD. International Scholarly Research Network 2011 2011-07-05 /pmc/articles/PMC3197074/ /pubmed/22084698 http://dx.doi.org/10.5402/2011/473152 Text en Copyright © 2011 P. C. Giordano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Giordano, P. C.
Huisman, W.
Harteveld, C. L.
Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?
title Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?
title_full Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?
title_fullStr Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?
title_full_unstemmed Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?
title_short Iron Depletion: An Ameliorating Factor for Sickle Cell Disease?
title_sort iron depletion: an ameliorating factor for sickle cell disease?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197074/
https://www.ncbi.nlm.nih.gov/pubmed/22084698
http://dx.doi.org/10.5402/2011/473152
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