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Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task

In this study, we recorded single unit activity from rat auditory cortex while the animals performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms, and go to the left or right nose poke accordingly. Spontaneous firing i...

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Autores principales: Abolafia, Juan M., Martinez-Garcia, Marina, Deco, Gustavo, Sanchez-Vives, Maria V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197084/
https://www.ncbi.nlm.nih.gov/pubmed/22022308
http://dx.doi.org/10.3389/fnint.2011.00060
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author Abolafia, Juan M.
Martinez-Garcia, Marina
Deco, Gustavo
Sanchez-Vives, Maria V.
author_facet Abolafia, Juan M.
Martinez-Garcia, Marina
Deco, Gustavo
Sanchez-Vives, Maria V.
author_sort Abolafia, Juan M.
collection PubMed
description In this study, we recorded single unit activity from rat auditory cortex while the animals performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms, and go to the left or right nose poke accordingly. Spontaneous firing in between auditory responses was compared in the attentive versus non-attentive brain states. We describe the firing rate modulation detected during intervals while there was no auditory stimulation. Nearly 18% of neurons (n = 14) showed a prominent neuronal discharge during the interstimulus interval, in the form of an upward or downward ramp towards the second auditory stimulus. These patterns of spontaneous activity were often modulated in the attentive versus passive trials. Modulation of the spontaneous firing rate during the task was observed not only between auditory stimuli, but also in the interval preceding the stimulus. These slow modulatory components could be locally generated or the result of a top-down influence originated in higher associative association areas. Such a neuronal discharge may be related to the computation of the interval time and contribute to the perception of the auditory stimulus.
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spelling pubmed-31970842011-10-21 Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task Abolafia, Juan M. Martinez-Garcia, Marina Deco, Gustavo Sanchez-Vives, Maria V. Front Integr Neurosci Neuroscience In this study, we recorded single unit activity from rat auditory cortex while the animals performed an interval-discrimination task. The animals had to decide whether two auditory stimuli were separated by either 150 or 300 ms, and go to the left or right nose poke accordingly. Spontaneous firing in between auditory responses was compared in the attentive versus non-attentive brain states. We describe the firing rate modulation detected during intervals while there was no auditory stimulation. Nearly 18% of neurons (n = 14) showed a prominent neuronal discharge during the interstimulus interval, in the form of an upward or downward ramp towards the second auditory stimulus. These patterns of spontaneous activity were often modulated in the attentive versus passive trials. Modulation of the spontaneous firing rate during the task was observed not only between auditory stimuli, but also in the interval preceding the stimulus. These slow modulatory components could be locally generated or the result of a top-down influence originated in higher associative association areas. Such a neuronal discharge may be related to the computation of the interval time and contribute to the perception of the auditory stimulus. Frontiers Research Foundation 2011-10-19 /pmc/articles/PMC3197084/ /pubmed/22022308 http://dx.doi.org/10.3389/fnint.2011.00060 Text en Copyright © 2011 Abolafia, Martinez-Garcia, Deco and Sanchez-Vives. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Abolafia, Juan M.
Martinez-Garcia, Marina
Deco, Gustavo
Sanchez-Vives, Maria V.
Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task
title Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task
title_full Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task
title_fullStr Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task
title_full_unstemmed Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task
title_short Slow Modulation of Ongoing Discharge in the Auditory Cortex during an Interval-Discrimination Task
title_sort slow modulation of ongoing discharge in the auditory cortex during an interval-discrimination task
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197084/
https://www.ncbi.nlm.nih.gov/pubmed/22022308
http://dx.doi.org/10.3389/fnint.2011.00060
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