Bioenergetic Consequences of PINK1 Mutations in Parkinson Disease

BACKGROUND: Mutations of the gene for PTEN-induced kinase 1 (PINK1) are a cause of familial Parkinson's disease (PD). PINK1 protein has been localised to mitochondria and PINK1 gene knockout models exhibit abnormal mitochondrial function. The purpose of this study was to determine whether cells...

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Detalles Bibliográficos
Autores principales: Abramov, Andrey Yurevich, Gegg, Matthew, Grunewald, Anne, Wood, Nicholas William, Klein, Christine, Schapira, Anthony Henry Vernon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197155/
https://www.ncbi.nlm.nih.gov/pubmed/22043288
http://dx.doi.org/10.1371/journal.pone.0025622

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