Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells

BACKGROUND: The small molecule Halofuginone (HF) is a potent regulator of extracellular matrix (ECM ) gene expression and is unique in its therapeutic potential. While the basis for HF effects is unknown, inhibition of TGFβ signaling and activation of the amino acid restriction response (AAR) have b...

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Detalles Bibliográficos
Autores principales: Kamberov, Yana G, Kim, Jihoon, Mazitschek, Ralph, Kuo, Winston P, Whitman, Malcolm
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197508/
https://www.ncbi.nlm.nih.gov/pubmed/21974968
http://dx.doi.org/10.1186/1756-0500-4-381

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