Genetic evidence for an essential role of neuronally expressed IL-6 signal transducer gp130 in the induction and maintenance of experimentally induced mechanical hypersensitivity in vivo and in vitro

Tenderness and mechanical allodynia are key symptoms of malignant tumor, inflammation and neuropathy. The proinflammatory cytokine interleukin-6 (IL-6) is causally involved in all three pathologies. IL-6 not only regulates innate immunity and inflammation but also causes nociceptor sensitization and...

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Detalles Bibliográficos
Autores principales: Quarta, Serena, Vogl, Christian, Constantin, Cristina E, Üçeyler, Nurcan, Sommer, Claudia, Kress, Michaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197546/
https://www.ncbi.nlm.nih.gov/pubmed/21951917
http://dx.doi.org/10.1186/1744-8069-7-73

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