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The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications
Regenerative strategies that facilitate the regrowth and reconnection of neurons are some of the most promising methods in spinal cord injury research. An essential part of these strategies is an increased understanding of the mechanisms by which growing neurites seek out and synapse with viable tar...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197581/ https://www.ncbi.nlm.nih.gov/pubmed/22028773 http://dx.doi.org/10.1371/journal.pone.0025135 |
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author | Oşan, Remus Su, Emily Shinbrot, Troy |
author_facet | Oşan, Remus Su, Emily Shinbrot, Troy |
author_sort | Oşan, Remus |
collection | PubMed |
description | Regenerative strategies that facilitate the regrowth and reconnection of neurons are some of the most promising methods in spinal cord injury research. An essential part of these strategies is an increased understanding of the mechanisms by which growing neurites seek out and synapse with viable targets. In this paper, we use computational and theoretical tools to examine the targeting efficiency of growing neurites subject to limited resources, such as maximum total neural tree length. We find that in order to efficiently reach a particular target, growing neurites must achieve balance between pruning and branching: rapidly growing neurites that do not prune will exhaust their resources, and frequently pruning neurites will fail to explore space effectively. We also find that the optimal branching/pruning balance must shift as the target distance changes: different strategies are called for to reach nearby vs. distant targets. This suggests the existence of a currently unidentified higher-level regulatory factor to control arborization dynamics. We propose that these findings may be useful in future therapies seeking to improve targeting rates through manipulation of arborization behaviors. |
format | Online Article Text |
id | pubmed-3197581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31975812011-10-25 The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications Oşan, Remus Su, Emily Shinbrot, Troy PLoS One Research Article Regenerative strategies that facilitate the regrowth and reconnection of neurons are some of the most promising methods in spinal cord injury research. An essential part of these strategies is an increased understanding of the mechanisms by which growing neurites seek out and synapse with viable targets. In this paper, we use computational and theoretical tools to examine the targeting efficiency of growing neurites subject to limited resources, such as maximum total neural tree length. We find that in order to efficiently reach a particular target, growing neurites must achieve balance between pruning and branching: rapidly growing neurites that do not prune will exhaust their resources, and frequently pruning neurites will fail to explore space effectively. We also find that the optimal branching/pruning balance must shift as the target distance changes: different strategies are called for to reach nearby vs. distant targets. This suggests the existence of a currently unidentified higher-level regulatory factor to control arborization dynamics. We propose that these findings may be useful in future therapies seeking to improve targeting rates through manipulation of arborization behaviors. Public Library of Science 2011-10-20 /pmc/articles/PMC3197581/ /pubmed/22028773 http://dx.doi.org/10.1371/journal.pone.0025135 Text en Oşan et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Oşan, Remus Su, Emily Shinbrot, Troy The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications |
title | The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications |
title_full | The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications |
title_fullStr | The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications |
title_full_unstemmed | The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications |
title_short | The Interplay between Branching and Pruning on Neuronal Target Search during Developmental Growth: Functional Role and Implications |
title_sort | interplay between branching and pruning on neuronal target search during developmental growth: functional role and implications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197581/ https://www.ncbi.nlm.nih.gov/pubmed/22028773 http://dx.doi.org/10.1371/journal.pone.0025135 |
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