Structural and Functional Analysis of Laninamivir and its Octanoate Prodrug Reveals Group Specific Mechanisms for Influenza NA Inhibition

The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA) inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant viruses. Therefore, development and careful evaluation of novel NA inhibitors is of great interest. Recently, a highly po...

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Detalles Bibliográficos
Autores principales: Vavricka, Christopher J., Li, Qing, Wu, Yan, Qi, Jianxun, Wang, Mingyang, Liu, Yue, Gao, Feng, Liu, Jun, Feng, Enguang, He, Jianhua, Wang, Jinfang, Liu, Hong, Jiang, Hualiang, Gao, George F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197600/
https://www.ncbi.nlm.nih.gov/pubmed/22028647
http://dx.doi.org/10.1371/journal.ppat.1002249

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