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A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum

Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. The fungus produces mycotoxins that are harmful to animal and human. In this study, a systematic analysis of 17 phenotypes of the mutants in 657 Fusarium graminearum genes encoding putative transcripti...

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Autores principales: Son, Hokyoung, Seo, Young-Su, Min, Kyunghun, Park, Ae Ran, Lee, Jungkwan, Jin, Jian-Ming, Lin, Yang, Cao, Peijian, Hong, Sae-Yeon, Kim, Eun-Kyung, Lee, Seung-Ho, Cho, Aram, Lee, Seunghoon, Kim, Myung-Gu, Kim, Yongsoo, Kim, Jung-Eun, Kim, Jin-Cheol, Choi, Gyung Ja, Yun, Sung-Hwan, Lim, Jae Yun, Kim, Minkyun, Lee, Yong-Hwan, Choi, Yang-Do, Lee, Yin-Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197617/
https://www.ncbi.nlm.nih.gov/pubmed/22028654
http://dx.doi.org/10.1371/journal.ppat.1002310
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author Son, Hokyoung
Seo, Young-Su
Min, Kyunghun
Park, Ae Ran
Lee, Jungkwan
Jin, Jian-Ming
Lin, Yang
Cao, Peijian
Hong, Sae-Yeon
Kim, Eun-Kyung
Lee, Seung-Ho
Cho, Aram
Lee, Seunghoon
Kim, Myung-Gu
Kim, Yongsoo
Kim, Jung-Eun
Kim, Jin-Cheol
Choi, Gyung Ja
Yun, Sung-Hwan
Lim, Jae Yun
Kim, Minkyun
Lee, Yong-Hwan
Choi, Yang-Do
Lee, Yin-Won
author_facet Son, Hokyoung
Seo, Young-Su
Min, Kyunghun
Park, Ae Ran
Lee, Jungkwan
Jin, Jian-Ming
Lin, Yang
Cao, Peijian
Hong, Sae-Yeon
Kim, Eun-Kyung
Lee, Seung-Ho
Cho, Aram
Lee, Seunghoon
Kim, Myung-Gu
Kim, Yongsoo
Kim, Jung-Eun
Kim, Jin-Cheol
Choi, Gyung Ja
Yun, Sung-Hwan
Lim, Jae Yun
Kim, Minkyun
Lee, Yong-Hwan
Choi, Yang-Do
Lee, Yin-Won
author_sort Son, Hokyoung
collection PubMed
description Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. The fungus produces mycotoxins that are harmful to animal and human. In this study, a systematic analysis of 17 phenotypes of the mutants in 657 Fusarium graminearum genes encoding putative transcription factors (TFs) resulted in a database of over 11,000 phenotypes (phenome). This database provides comprehensive insights into how this cereal pathogen of global significance regulates traits important for growth, development, stress response, pathogenesis, and toxin production and how transcriptional regulations of these traits are interconnected. In-depth analysis of TFs involved in sexual development revealed that mutations causing defects in perithecia development frequently affect multiple other phenotypes, and the TFs associated with sexual development tend to be highly conserved in the fungal kingdom. Besides providing many new insights into understanding the function of F. graminearum TFs, this mutant library and phenome will be a valuable resource for characterizing the gene expression network in this fungus and serve as a reference for studying how different fungi have evolved to control various cellular processes at the transcriptional level.
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spelling pubmed-31976172011-10-25 A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum Son, Hokyoung Seo, Young-Su Min, Kyunghun Park, Ae Ran Lee, Jungkwan Jin, Jian-Ming Lin, Yang Cao, Peijian Hong, Sae-Yeon Kim, Eun-Kyung Lee, Seung-Ho Cho, Aram Lee, Seunghoon Kim, Myung-Gu Kim, Yongsoo Kim, Jung-Eun Kim, Jin-Cheol Choi, Gyung Ja Yun, Sung-Hwan Lim, Jae Yun Kim, Minkyun Lee, Yong-Hwan Choi, Yang-Do Lee, Yin-Won PLoS Pathog Research Article Fusarium graminearum is an important plant pathogen that causes head blight of major cereal crops. The fungus produces mycotoxins that are harmful to animal and human. In this study, a systematic analysis of 17 phenotypes of the mutants in 657 Fusarium graminearum genes encoding putative transcription factors (TFs) resulted in a database of over 11,000 phenotypes (phenome). This database provides comprehensive insights into how this cereal pathogen of global significance regulates traits important for growth, development, stress response, pathogenesis, and toxin production and how transcriptional regulations of these traits are interconnected. In-depth analysis of TFs involved in sexual development revealed that mutations causing defects in perithecia development frequently affect multiple other phenotypes, and the TFs associated with sexual development tend to be highly conserved in the fungal kingdom. Besides providing many new insights into understanding the function of F. graminearum TFs, this mutant library and phenome will be a valuable resource for characterizing the gene expression network in this fungus and serve as a reference for studying how different fungi have evolved to control various cellular processes at the transcriptional level. Public Library of Science 2011-10-20 /pmc/articles/PMC3197617/ /pubmed/22028654 http://dx.doi.org/10.1371/journal.ppat.1002310 Text en Son et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Son, Hokyoung
Seo, Young-Su
Min, Kyunghun
Park, Ae Ran
Lee, Jungkwan
Jin, Jian-Ming
Lin, Yang
Cao, Peijian
Hong, Sae-Yeon
Kim, Eun-Kyung
Lee, Seung-Ho
Cho, Aram
Lee, Seunghoon
Kim, Myung-Gu
Kim, Yongsoo
Kim, Jung-Eun
Kim, Jin-Cheol
Choi, Gyung Ja
Yun, Sung-Hwan
Lim, Jae Yun
Kim, Minkyun
Lee, Yong-Hwan
Choi, Yang-Do
Lee, Yin-Won
A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
title A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
title_full A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
title_fullStr A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
title_full_unstemmed A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
title_short A Phenome-Based Functional Analysis of Transcription Factors in the Cereal Head Blight Fungus, Fusarium graminearum
title_sort phenome-based functional analysis of transcription factors in the cereal head blight fungus, fusarium graminearum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197617/
https://www.ncbi.nlm.nih.gov/pubmed/22028654
http://dx.doi.org/10.1371/journal.ppat.1002310
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