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Ensemble-Based Computational Approach Discriminates Functional Activity of p53 Cancer and Rescue Mutants
The tumor suppressor protein p53 can lose its function upon single-point missense mutations in the core DNA-binding domain (“cancer mutants”). Activity can be restored by second-site suppressor mutations (“rescue mutants”). This paper relates the functional activity of p53 cancer and rescue mutants...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197647/ https://www.ncbi.nlm.nih.gov/pubmed/22028641 http://dx.doi.org/10.1371/journal.pcbi.1002238 |