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NHE Inhibition Does Not Improve Na(+) or Ca(2+) Overload During Reperfusion: Using Modeling to Illuminate the Mechanisms Underlying a Therapeutic Failure
Reperfusion injury results from pathologies of cardiac myocyte physiology that develop when previously ischemic myocardium experiences a restoration of normal perfusion. Events in the development of reperfusion injury begin with the restoration of a proton gradient upon reperfusion, which then allow...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197652/ https://www.ncbi.nlm.nih.gov/pubmed/22028644 http://dx.doi.org/10.1371/journal.pcbi.1002241 |