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Structural Insight of Dopamine β-Hydroxylase, a Drug Target for Complex Traits, and Functional Significance of Exonic Single Nucleotide Polymorphisms

BACKGROUND: Human dopamine β-hydroxylase (DBH) is an important therapeutic target for complex traits. Several single nucleotide polymorphisms (SNPs) have also been identified in DBH with potential adverse physiological effect. However, difficulty in obtaining diffractable crystals and lack of a suit...

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Detalles Bibliográficos
Autores principales:	Kapoor, Abhijeet, Shandilya, Manish, Kundu, Suman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197665/ https://www.ncbi.nlm.nih.gov/pubmed/22028891 http://dx.doi.org/10.1371/journal.pone.0026509

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