A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants th...

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Detalles Bibliográficos
Autores principales: Surakka, Ida, Isaacs, Aaron, Karssen, Lennart C., Laurila, Pirkka-Pekka P., Middelberg, Rita P. S., Tikkanen, Emmi, Ried, Janina S., Lamina, Claudia, Mangino, Massimo, Igl, Wilmar, Hottenga, Jouke-Jan, Lagou, Vasiliki, van der Harst, Pim, Mateo Leach, Irene, Esko, Tõnu, Kutalik, Zoltán, Wainwright, Nicholas W., Struchalin, Maksim V., Sarin, Antti-Pekka, Kangas, Antti J., Viikari, Jorma S., Perola, Markus, Rantanen, Taina, Petersen, Ann-Kristin, Soininen, Pasi, Johansson, Åsa, Soranzo, Nicole, Heath, Andrew C., Papamarkou, Theodore, Prokopenko, Inga, Tönjes, Anke, Kronenberg, Florian, Döring, Angela, Rivadeneira, Fernando, Montgomery, Grant W., Whitfield, John B., Kähönen, Mika, Lehtimäki, Terho, Freimer, Nelson B., Willemsen, Gonneke, de Geus, Eco J. C., Palotie, Aarno, Sandhu, Manj S., Waterworth, Dawn M., Metspalu, Andres, Stumvoll, Michael, Uitterlinden, André G., Jula, Antti, Navis, Gerjan, Wijmenga, Cisca, Wolffenbuttel, Bruce H. R., Taskinen, Marja-Riitta, Ala-Korpela, Mika, Kaprio, Jaakko, Kyvik, Kirsten O., Boomsma, Dorret I., Pedersen, Nancy L., Gyllensten, Ulf, Wilson, James F., Rudan, Igor, Campbell, Harry, Pramstaller, Peter P., Spector, Tim D., Witteman, Jacqueline C. M., Eriksson, Johan G., Salomaa, Veikko, Oostra, Ben A., Raitakari, Olli T., Wichmann, H.-Erich, Gieger, Christian, Järvelin, Marjo-Riitta, Martin, Nicholas G., Hofman, Albert, McCarthy, Mark I., Peltonen, Leena, van Duijn, Cornelia M., Aulchenko, Yurii S., Ripatti, Samuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197672/
https://www.ncbi.nlm.nih.gov/pubmed/22028671
http://dx.doi.org/10.1371/journal.pgen.1002333

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