Ligand Discovery from a Dopamine D(3) Receptor Homology Model and Crystal Structure

G-Protein coupled receptors (GPCRs) are intensely studied as drug targets and for their role in signaling. With the determination of the first crystal structures, interest in structure-based ligand discovery has increased. Unfortunately, most GPCRs lack experimental structures. The determination of...

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Detalles Bibliográficos
Autores principales: Carlsson, Jens, Coleman, Ryan G., Setola, Vincent, Irwin, John J., Fan, Hao, Schlessinger, Avner, Sali, Andrej, Roth, Bryan L., Shoichet, Brian K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197762/
https://www.ncbi.nlm.nih.gov/pubmed/21926995
http://dx.doi.org/10.1038/nchembio.662

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