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A novel motif in the V3 domain of PKC-θ determines its immunological synapse localization and functions in T cells via association with CD28

Protein kinase C-θ (PKC-θ) translocates to the center of the immunological synapse, but the underlying mechanism and its importance in T cell activation are unknown. We found that the PKC-θ V3 domain is necessary and sufficient for IS localization mediated by Lck-dependent association with CD28. We...

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Detalles Bibliográficos
Autores principales:	Kong, Kok-Fai, Yokosuka, Tadashi, Canonigo-Balancio, Ann J., Isakov, Noah, Saito, Takashi, Altman, Amnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197934/ https://www.ncbi.nlm.nih.gov/pubmed/21964608 http://dx.doi.org/10.1038/ni.2120

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