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Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

OBJECTIVE: To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic α-cells and how this sudden massive depletion affects β-cell function and blood glucose homeostasis. RESEARCH DESIGN AND METHODS: We generated a new transgenic model allowing near-total α-cell re...

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Detalles Bibliográficos
Autores principales:	Thorel, Fabrizio, Damond, Nicolas, Chera, Simona, Wiederkehr, Andreas, Thorens, Bernard, Meda, Paolo, Wollheim, Claes B., Herrera, Pedro L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198058/ https://www.ncbi.nlm.nih.gov/pubmed/21926270 http://dx.doi.org/10.2337/db11-0876

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