Cargando…

Arginase-2 Mediates Diabetic Renal Injury

OBJECTIVE: To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN). RESEARCH DESIGN AND METHODS: The impact of arginase activity and expression on renal damage was evaluated in spontaneous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morris, Sidney M., Gao, Ting, Cooper, Timothy K., Kepka-Lenhart, Diane, Awad, Alaa S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198072/ https://www.ncbi.nlm.nih.gov/pubmed/21926276 http://dx.doi.org/10.2337/db11-0901

Ejemplares similares

Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism
por: You, Hanning, et al.
Publicado: (2013)

Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy
por: Xiao, Li, et al.
Publicado: (2014)

Catalase Deficiency Accelerates Diabetic Renal Injury Through Peroxisomal Dysfunction
por: Hwang, Inah, et al.
Publicado: (2012)

HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice
por: Nayak, Bijaya K., et al.
Publicado: (2016)

Drp1-Mediated Mitochondrial Abnormalities Link to Synaptic Injury in Diabetes Model
por: Huang, Shengbin, et al.
Publicado: (2015)

Early-Outgrowth Bone Marrow Cells Attenuate Renal Injury and Dysfunction via an Antioxidant Effect in a Mouse Model of Type 2 Diabetes
por: Zhang, Yanling, et al.
Publicado: (2012)

Catalase Overexpression Prevents Nuclear Factor Erythroid 2–Related Factor 2 Stimulation of Renal Angiotensinogen Gene Expression, Hypertension, and Kidney Injury in Diabetic Mice
por: Abdo, Shaaban, et al.
Publicado: (2014)

Haptoglobin Genotype and Renal Function Decline in Type 1 Diabetes
por: Costacou, Tina, et al.
Publicado: (2009)

Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes
por: Saulnier, Pierre-Jean, et al.
Publicado: (2016)

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium
por: Bucciarelli, Loredana G., et al.
Publicado: (2008)

Bcl-2–Modifying Factor Induces Renal Proximal Tubular Cell Apoptosis in Diabetic Mice
por: Lau, Garnet J., et al.
Publicado: (2012)

Hypohalous Acids Contribute to Renal Extracellular Matrix Damage in Experimental Diabetes
por: Brown, Kyle L., et al.
Publicado: (2015)

REDD1 Ablation Attenuates the Development of Renal Complications in Diabetic Mice
por: Sunilkumar, Siddharth, et al.
Publicado: (2022)

Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy
por: Gu, Junlian, et al.
Publicado: (2017)

Fetal Exposure to Maternal Type 1 Diabetes Is Associated With Renal Dysfunction at Adult Age
por: Khalil, Charbel Abi, et al.
Publicado: (2010)

Enhanced Integrin α4β1–Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes
por: Abplanalp, Wesley T., et al.
Publicado: (2016)

miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression
por: Wang, Bo, et al.
Publicado: (2011)

Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
por: Nehiri, Touria, et al.
Publicado: (2008)

Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α
por: Zheng, Zhi, et al.
Publicado: (2010)

Increased Inner Ear Susceptibility to Noise Injury in Mice With Streptozotocin-Induced Diabetes
por: Fujita, Takeshi, et al.
Publicado: (2012)

Decreased Cerebrovascular Brain-Derived Neurotrophic Factor–Mediated Neuroprotection in the Diabetic Brain
por: Navaratna, Deepti, et al.
Publicado: (2011)

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse
por: Reiniger, Nina, et al.
Publicado: (2010)

Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats
por: Clermont, Allen, et al.
Publicado: (2011)

The RANKL/RANK/OPG Signaling Pathway Mediates Medial Arterial Calcification in Diabetic Charcot Neuroarthropathy
por: Ndip, Agbor, et al.
Publicado: (2011)

miR-146a–Mediated Extracellular Matrix Protein Production in Chronic Diabetes Complications
por: Feng, Biao, et al.
Publicado: (2011)

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission
por: Wang, Qilong, et al.
Publicado: (2017)

Nitrite Anion Therapy Protects Against Chronic Ischemic Tissue Injury in db/db Diabetic Mice in a NO/VEGF-Dependent Manner
por: Bir, Shyamal C., et al.
Publicado: (2014)

Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes
por: Wang, Zongwei, et al.
Publicado: (2012)

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex
por: Zhang, Quan-Jiang, et al.
Publicado: (2012)

Therapeutic Effects of PPARα Agonists on Diabetic Retinopathy in Type 1 Diabetes Models
por: Chen, Ying, et al.
Publicado: (2013)

Progressive Axonal Dysfunction Precedes Development of Neuropathy in Type 2 Diabetes
por: Sung, Jia-Ying, et al.
Publicado: (2012)

Heterogeneous Nuclear Ribonucleoprotein F Suppresses Angiotensinogen Gene Expression and Attenuates Hypertension and Kidney Injury in Diabetic Mice
por: Lo, Chao-Sheng, et al.
Publicado: (2012)

MicroRNA-200b Regulates Vascular Endothelial Growth Factor–Mediated Alterations in Diabetic Retinopathy
por: McArthur, Kara, et al.
Publicado: (2011)

Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin: A Possible Role of HIF-1α Expression and Oxygen Metabolism
por: Takiyama, Yumi, et al.
Publicado: (2011)

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice
por: Mirza, Rita E., et al.
Publicado: (2014)

Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 Diabetes: The CACTI Study
por: Schauer, Irene E., et al.
Publicado: (2011)

Protein Kinase C-δ Mediates Neuronal Apoptosis in the Retinas of Diabetic Rats via the Akt Signaling Pathway
por: Kim, Young-Hee, et al.
Publicado: (2008)

CD40 in Retinal Müller Cells Induces P2X(7)-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
por: Portillo, Jose-Andres C., et al.
Publicado: (2017)

Sulfasalazine Blocks the Development of Tactile Allodynia in Diabetic Rats
por: Berti-Mattera, Liliana N., et al.
Publicado: (2008)

Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor-β: A Model for Diabetic Podocytopathy
por: Herman-Edelstein, Michal, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bthp9l5gh8hta06sl5q82bvn20