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Loss of Intra-Islet CD20 Expression May Complicate Efficacy of B-Cell–Directed Type 1 Diabetes Therapies

OBJECTIVE: Consistent with studies in NOD mice, early clinical trials addressing whether depletion of B cells by the Rituximab CD20-specific antibody provides an effective means for type 1 diabetes reversal have produced promising results. However, to improve therapeutic efficacy, additional B-cell–...

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Detalles Bibliográficos
Autores principales:	Serreze, David V., Chapman, Harold D., Niens, Marijke, Dunn, Robert, Kehry, Marilyn R., Driver, John P., Haller, Michael, Wasserfall, Clive, Atkinson, Mark A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198088/ https://www.ncbi.nlm.nih.gov/pubmed/21926271 http://dx.doi.org/10.2337/db11-0705

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