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FoxO Feedback Control of Basal IRS-2 Expression in Pancreatic β-Cells Is Distinct From That in Hepatocytes

OBJECTIVE: Appropriate regulation of insulin receptor substrate 2 (IRS-2) expression in pancreatic β-cells is essential to adequately compensate for insulin resistance. In liver, basal IRS-2 expression is controlled via a temporal negative feedback of sterol regulatory element–binding protein 1 (SRE...

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Detalles Bibliográficos
Autores principales:	Tsunekawa, Shin, Demozay, Damien, Briaud, Isabelle, McCuaig, Jill, Accili, Domenico, Stein, Roland, Rhodes, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198101/ https://www.ncbi.nlm.nih.gov/pubmed/21933986 http://dx.doi.org/10.2337/db11-0340

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