Cargando…

Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus

Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavio...

Descripción completa

Detalles Bibliográficos
Autores principales: Dendrinos, Georgia, Hemelt, Marie, Keller, Asaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198155/
https://www.ncbi.nlm.nih.gov/pubmed/22025911
http://dx.doi.org/10.3389/fnint.2011.00068
_version_ 1782214386296815616
author Dendrinos, Georgia
Hemelt, Marie
Keller, Asaf
author_facet Dendrinos, Georgia
Hemelt, Marie
Keller, Asaf
author_sort Dendrinos, Georgia
collection PubMed
description Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.
format Online
Article
Text
id pubmed-3198155
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-31981552011-10-24 Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus Dendrinos, Georgia Hemelt, Marie Keller, Asaf Front Integr Neurosci Neuroscience Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing. Frontiers Research Foundation 2011-10-20 /pmc/articles/PMC3198155/ /pubmed/22025911 http://dx.doi.org/10.3389/fnint.2011.00068 Text en Copyright © 2011 Dendrinos, Hemelt and Keller. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Dendrinos, Georgia
Hemelt, Marie
Keller, Asaf
Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus
title Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus
title_full Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus
title_fullStr Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus
title_full_unstemmed Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus
title_short Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus
title_sort prenatal vpa exposure and changes in sensory processing by the superior colliculus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198155/
https://www.ncbi.nlm.nih.gov/pubmed/22025911
http://dx.doi.org/10.3389/fnint.2011.00068
work_keys_str_mv AT dendrinosgeorgia prenatalvpaexposureandchangesinsensoryprocessingbythesuperiorcolliculus
AT hemeltmarie prenatalvpaexposureandchangesinsensoryprocessingbythesuperiorcolliculus
AT kellerasaf prenatalvpaexposureandchangesinsensoryprocessingbythesuperiorcolliculus