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Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
OBJECTIVE: The validity of HbA(1c) as a population diagnostic tool was tested against oral glucose tolerance testing in Abu Dhabi nationals. RESEARCH DESIGN AND METHODS: The screening tool of HbA(1c) and random glucose was validated against the “gold standard” oral glucose tolerance test according t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198299/ https://www.ncbi.nlm.nih.gov/pubmed/21926284 http://dx.doi.org/10.2337/dc11-0284 |
Sumario: | OBJECTIVE: The validity of HbA(1c) as a population diagnostic tool was tested against oral glucose tolerance testing in Abu Dhabi nationals. RESEARCH DESIGN AND METHODS: The screening tool of HbA(1c) and random glucose was validated against the “gold standard” oral glucose tolerance test according to World Health Organization criteria. RESULTS: The HbA(1c) threshold of 6.4% provided the optimum balance between sensitivity (72.0%) and specificity (84.3%) with positive and negative predictive values of 47.9 and 93.7% and area under the receiver operating characteristics curve of 0.78. This threshold compares with a threshold of 6.5% recommended by the International Scientific Committee and American Diabetes Association and of 6.3% in a recent study in China. CONCLUSIONS: This study successfully validates the feasibility and threshold of HbA(1c) for diagnosis of diabetes at the population level in a Middle-Eastern population. This result is a major step in the fight to tackle the increasing burden of diabetes in the United Arab Emirates. |
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