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Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program

OBJECTIVE: The validity of HbA(1c) as a population diagnostic tool was tested against oral glucose tolerance testing in Abu Dhabi nationals. RESEARCH DESIGN AND METHODS: The screening tool of HbA(1c) and random glucose was validated against the “gold standard” oral glucose tolerance test according t...

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Detalles Bibliográficos
Autores principales: Hajat, Cother, Harrison, Oliver, Al Siksek, Zaid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198299/
https://www.ncbi.nlm.nih.gov/pubmed/21926284
http://dx.doi.org/10.2337/dc11-0284
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author Hajat, Cother
Harrison, Oliver
Al Siksek, Zaid
author_facet Hajat, Cother
Harrison, Oliver
Al Siksek, Zaid
author_sort Hajat, Cother
collection PubMed
description OBJECTIVE: The validity of HbA(1c) as a population diagnostic tool was tested against oral glucose tolerance testing in Abu Dhabi nationals. RESEARCH DESIGN AND METHODS: The screening tool of HbA(1c) and random glucose was validated against the “gold standard” oral glucose tolerance test according to World Health Organization criteria. RESULTS: The HbA(1c) threshold of 6.4% provided the optimum balance between sensitivity (72.0%) and specificity (84.3%) with positive and negative predictive values of 47.9 and 93.7% and area under the receiver operating characteristics curve of 0.78. This threshold compares with a threshold of 6.5% recommended by the International Scientific Committee and American Diabetes Association and of 6.3% in a recent study in China. CONCLUSIONS: This study successfully validates the feasibility and threshold of HbA(1c) for diagnosis of diabetes at the population level in a Middle-Eastern population. This result is a major step in the fight to tackle the increasing burden of diabetes in the United Arab Emirates.
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spelling pubmed-31982992012-11-01 Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program Hajat, Cother Harrison, Oliver Al Siksek, Zaid Diabetes Care Original Research OBJECTIVE: The validity of HbA(1c) as a population diagnostic tool was tested against oral glucose tolerance testing in Abu Dhabi nationals. RESEARCH DESIGN AND METHODS: The screening tool of HbA(1c) and random glucose was validated against the “gold standard” oral glucose tolerance test according to World Health Organization criteria. RESULTS: The HbA(1c) threshold of 6.4% provided the optimum balance between sensitivity (72.0%) and specificity (84.3%) with positive and negative predictive values of 47.9 and 93.7% and area under the receiver operating characteristics curve of 0.78. This threshold compares with a threshold of 6.5% recommended by the International Scientific Committee and American Diabetes Association and of 6.3% in a recent study in China. CONCLUSIONS: This study successfully validates the feasibility and threshold of HbA(1c) for diagnosis of diabetes at the population level in a Middle-Eastern population. This result is a major step in the fight to tackle the increasing burden of diabetes in the United Arab Emirates. American Diabetes Association 2011-11 2011-10-15 /pmc/articles/PMC3198299/ /pubmed/21926284 http://dx.doi.org/10.2337/dc11-0284 Text en © 2011 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Original Research
Hajat, Cother
Harrison, Oliver
Al Siksek, Zaid
Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
title Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
title_full Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
title_fullStr Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
title_full_unstemmed Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
title_short Diagnostic Testing for Diabetes Using HbA(1c) in the Abu Dhabi Population: Weqaya: the Abu Dhabi Cardiovascular Screening Program
title_sort diagnostic testing for diabetes using hba(1c) in the abu dhabi population: weqaya: the abu dhabi cardiovascular screening program
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198299/
https://www.ncbi.nlm.nih.gov/pubmed/21926284
http://dx.doi.org/10.2337/dc11-0284
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