High-Dose siRNAs Upregulate Mouse Eri-1 at both Transcription and Posttranscription Levels

The eri-1 gene encodes a 3′ exonuclease that can negatively regulate RNA interference via siRNase activity. High-dose siRNAs (hd-siRNAs) can enhance Eri-1 expression, which in return degrade siRNAs and greatly reduces RNAi efficiency. Here we report that hd-siRNAs induce mouse Eri-1 (meri-1) express...

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Detalles Bibliográficos
Autores principales: Bian, Yingnan, Zhou, Wei, Zhao, Yingchun, Li, Xiaoping, Geng, Wei, Hao, Ruixin, Yang, Qing, Huang, Weida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198429/
https://www.ncbi.nlm.nih.gov/pubmed/22039495
http://dx.doi.org/10.1371/journal.pone.0026466

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198429/
https://www.ncbi.nlm.nih.gov/pubmed/22039495
http://dx.doi.org/10.1371/journal.pone.0026466

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