Cargando…

Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study

Diagnosis of patients with a disorder of consciousness is very challenging. Previous studies investigating resting state networks demonstrate that 2 main features of the so-called default mode network (DMN), metabolism and functional connectivity, are impaired in patients with a disorder of consciou...

Descripción completa

Detalles Bibliográficos
Autores principales: Crone, Julia Sophia, Ladurner, Gunther, Höller, Yvonne, Golaszewski, Stefan, Trinka, Eugen, Kronbichler, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198462/
https://www.ncbi.nlm.nih.gov/pubmed/22039473
http://dx.doi.org/10.1371/journal.pone.0026373
_version_ 1782214430390484992
author Crone, Julia Sophia
Ladurner, Gunther
Höller, Yvonne
Golaszewski, Stefan
Trinka, Eugen
Kronbichler, Martin
author_facet Crone, Julia Sophia
Ladurner, Gunther
Höller, Yvonne
Golaszewski, Stefan
Trinka, Eugen
Kronbichler, Martin
author_sort Crone, Julia Sophia
collection PubMed
description Diagnosis of patients with a disorder of consciousness is very challenging. Previous studies investigating resting state networks demonstrate that 2 main features of the so-called default mode network (DMN), metabolism and functional connectivity, are impaired in patients with a disorder of consciousness. However, task-induced deactivation – a third main feature of the DMN – has not been explored in a group of patients. Deactivation of the DMN is supposed to reflect interruptions of introspective processes. Seventeen patients with unresponsive wakefulness syndrome (UWS, former vegetative state), 8 patients in minimally conscious state (MCS), and 25 healthy controls were investigated with functional magnetic resonance imaging during a passive sentence listening task. Results show that deactivation in medial regions is reduced in MCS and absent in UWS patients compared to healthy controls. Moreover, behavioral scores assessing the level of consciousness correlate with deactivation in patients. On single-subject level, all control subjects but only 2 patients in MCS and 6 with UWS exposed deactivation. Interestingly, all patients who deactivated during speech processing (except for one) showed activation in left frontal regions which are associated with conscious processing. Our results indicate that deactivation of the DMN can be associated with the level of consciousness by selecting those who are able to interrupt ongoing introspective processes. In consequence, deactivation of the DMN may function as a marker of consciousness.
format Online
Article
Text
id pubmed-3198462
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-31984622011-10-28 Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study Crone, Julia Sophia Ladurner, Gunther Höller, Yvonne Golaszewski, Stefan Trinka, Eugen Kronbichler, Martin PLoS One Research Article Diagnosis of patients with a disorder of consciousness is very challenging. Previous studies investigating resting state networks demonstrate that 2 main features of the so-called default mode network (DMN), metabolism and functional connectivity, are impaired in patients with a disorder of consciousness. However, task-induced deactivation – a third main feature of the DMN – has not been explored in a group of patients. Deactivation of the DMN is supposed to reflect interruptions of introspective processes. Seventeen patients with unresponsive wakefulness syndrome (UWS, former vegetative state), 8 patients in minimally conscious state (MCS), and 25 healthy controls were investigated with functional magnetic resonance imaging during a passive sentence listening task. Results show that deactivation in medial regions is reduced in MCS and absent in UWS patients compared to healthy controls. Moreover, behavioral scores assessing the level of consciousness correlate with deactivation in patients. On single-subject level, all control subjects but only 2 patients in MCS and 6 with UWS exposed deactivation. Interestingly, all patients who deactivated during speech processing (except for one) showed activation in left frontal regions which are associated with conscious processing. Our results indicate that deactivation of the DMN can be associated with the level of consciousness by selecting those who are able to interrupt ongoing introspective processes. In consequence, deactivation of the DMN may function as a marker of consciousness. Public Library of Science 2011-10-19 /pmc/articles/PMC3198462/ /pubmed/22039473 http://dx.doi.org/10.1371/journal.pone.0026373 Text en Crone et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Crone, Julia Sophia
Ladurner, Gunther
Höller, Yvonne
Golaszewski, Stefan
Trinka, Eugen
Kronbichler, Martin
Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study
title Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study
title_full Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study
title_fullStr Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study
title_full_unstemmed Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study
title_short Deactivation of the Default Mode Network as a Marker of Impaired Consciousness: An fMRI Study
title_sort deactivation of the default mode network as a marker of impaired consciousness: an fmri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198462/
https://www.ncbi.nlm.nih.gov/pubmed/22039473
http://dx.doi.org/10.1371/journal.pone.0026373
work_keys_str_mv AT cronejuliasophia deactivationofthedefaultmodenetworkasamarkerofimpairedconsciousnessanfmristudy
AT ladurnergunther deactivationofthedefaultmodenetworkasamarkerofimpairedconsciousnessanfmristudy
AT holleryvonne deactivationofthedefaultmodenetworkasamarkerofimpairedconsciousnessanfmristudy
AT golaszewskistefan deactivationofthedefaultmodenetworkasamarkerofimpairedconsciousnessanfmristudy
AT trinkaeugen deactivationofthedefaultmodenetworkasamarkerofimpairedconsciousnessanfmristudy
AT kronbichlermartin deactivationofthedefaultmodenetworkasamarkerofimpairedconsciousnessanfmristudy