Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells

Mutations in the bone morphogenetic protein type II receptor gene (BMPR-II) are the major cause of heritable pulmonary arterial hypertension (PAH). Although both endothelial and smooth muscle cell BMPR-II dysfunction have been seen to contribute to pulmonary hypertension in vivo, little is known abo...

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Detalles Bibliográficos
Autores principales: Yang, Xudong, Long, Lu, Reynolds, Paul N., Morrell, Nicholas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198633/
https://www.ncbi.nlm.nih.gov/pubmed/22034596
http://dx.doi.org/10.4103/2045-8932.78100

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