Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade

BACKGROUND: Reactive oxygen species (ROS), superoxide and hydrogen peroxide (H(2)O(2)), are necessary for appropriate responses to immune challenges. In the brain, excess superoxide production predicts neuronal cell loss, suggesting that Parkinson's disease (PD) with its wholesale death of dopa...

Descripción completa

Detalles Bibliográficos
Autores principales: Zawada, W Michael, Banninger, Gregg P, Thornton, Jennifer, Marriott, Beth, Cantu, David, Rachubinski, Angela L, Das, Mita, Griffin, W Sue T, Jones, Susan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198931/
https://www.ncbi.nlm.nih.gov/pubmed/21975039
http://dx.doi.org/10.1186/1742-2094-8-129

Ejemplares similares

Ejemplares similares