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HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)

BACKGROUND: Project Accept is a community randomized, controlled trial to evaluate the efficacy of community mobilization, mobile testing, same-day results, and post-test support for the prevention of HIV infection in Thailand, Tanzania, Zimbabwe, and South Africa. We evaluated the accuracy of in-co...

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Autores principales: Piwowar-Manning, Estelle, Fiamma, Agnes, Laeyendecker, Oliver, Kulich, Michal, Donnell, Deborah, Szekeres, Greg, Robins-Morris, Laura, Mullis,, Caroline E, Vallari, Ana, Hackett, John, Mastro, Timothy D, Gray, Glenda, Richter, Linda, Alexandre, Michel W, Chariyalertsak, Suwat, Chingono,, Alfred, Sweat, Michael, Coates, Thomas, Eshleman, Susan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198953/
https://www.ncbi.nlm.nih.gov/pubmed/21943026
http://dx.doi.org/10.1186/1471-2334-11-251
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author Piwowar-Manning, Estelle
Fiamma, Agnes
Laeyendecker, Oliver
Kulich, Michal
Donnell, Deborah
Szekeres, Greg
Robins-Morris, Laura
Mullis,, Caroline E
Vallari, Ana
Hackett, John
Mastro, Timothy D
Gray, Glenda
Richter, Linda
Alexandre, Michel W
Chariyalertsak, Suwat
Chingono,, Alfred
Sweat, Michael
Coates, Thomas
Eshleman, Susan H
author_facet Piwowar-Manning, Estelle
Fiamma, Agnes
Laeyendecker, Oliver
Kulich, Michal
Donnell, Deborah
Szekeres, Greg
Robins-Morris, Laura
Mullis,, Caroline E
Vallari, Ana
Hackett, John
Mastro, Timothy D
Gray, Glenda
Richter, Linda
Alexandre, Michel W
Chariyalertsak, Suwat
Chingono,, Alfred
Sweat, Michael
Coates, Thomas
Eshleman, Susan H
author_sort Piwowar-Manning, Estelle
collection PubMed
description BACKGROUND: Project Accept is a community randomized, controlled trial to evaluate the efficacy of community mobilization, mobile testing, same-day results, and post-test support for the prevention of HIV infection in Thailand, Tanzania, Zimbabwe, and South Africa. We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study. METHODS: Two HIV rapid tests were performed in parallel in local laboratories. If the first two rapid tests were discordant (one reactive, one non-reactive), a third HIV rapid test or enzyme immunoassay was performed. Samples were designated HIV NEG if the first two tests were non-reactive, HIV DISC if the first two tests were discordant, and HIV POS if the first two tests were reactive. Samples were re-analyzed in the United States using a panel of laboratory tests. RESULTS: HIV infection status was correctly determined based on-in country testing for 2,236 (99.5%) of 2,247 participants [7 (0.37%) of 1,907 HIV NEG samples were HIV-positive; 2 (0.63%) of 317 HIV POS samples were HIV-negative; 2 (8.3%) of 24 HIV DISC samples were incorrectly identified as HIV-positive based on the in-country tie-breaker test]. HIV prevalence was: Thailand: 0.6%, Tanzania: 5.0%, Zimbabwe 14.7%, Soweto South Africa: 19.4%, Vulindlela, South Africa: 24.4%, (overall prevalence: 14.4%). CONCLUSIONS: In-country testing based on two HIV rapid tests correctly identified the HIV infection status for 99.5% of study participants; most participants with discordant HIV rapid tests were not infected. HIV prevalence varied considerably across the study sites (range: 0.6% to 24.4%). TRIAL REGISTRATION: ClinicalTrials.gov registry number NCT00203749.
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spelling pubmed-31989532011-10-23 HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043) Piwowar-Manning, Estelle Fiamma, Agnes Laeyendecker, Oliver Kulich, Michal Donnell, Deborah Szekeres, Greg Robins-Morris, Laura Mullis,, Caroline E Vallari, Ana Hackett, John Mastro, Timothy D Gray, Glenda Richter, Linda Alexandre, Michel W Chariyalertsak, Suwat Chingono,, Alfred Sweat, Michael Coates, Thomas Eshleman, Susan H BMC Infect Dis Research Article BACKGROUND: Project Accept is a community randomized, controlled trial to evaluate the efficacy of community mobilization, mobile testing, same-day results, and post-test support for the prevention of HIV infection in Thailand, Tanzania, Zimbabwe, and South Africa. We evaluated the accuracy of in-country HIV rapid testing and determined HIV prevalence in the Project Accept pilot study. METHODS: Two HIV rapid tests were performed in parallel in local laboratories. If the first two rapid tests were discordant (one reactive, one non-reactive), a third HIV rapid test or enzyme immunoassay was performed. Samples were designated HIV NEG if the first two tests were non-reactive, HIV DISC if the first two tests were discordant, and HIV POS if the first two tests were reactive. Samples were re-analyzed in the United States using a panel of laboratory tests. RESULTS: HIV infection status was correctly determined based on-in country testing for 2,236 (99.5%) of 2,247 participants [7 (0.37%) of 1,907 HIV NEG samples were HIV-positive; 2 (0.63%) of 317 HIV POS samples were HIV-negative; 2 (8.3%) of 24 HIV DISC samples were incorrectly identified as HIV-positive based on the in-country tie-breaker test]. HIV prevalence was: Thailand: 0.6%, Tanzania: 5.0%, Zimbabwe 14.7%, Soweto South Africa: 19.4%, Vulindlela, South Africa: 24.4%, (overall prevalence: 14.4%). CONCLUSIONS: In-country testing based on two HIV rapid tests correctly identified the HIV infection status for 99.5% of study participants; most participants with discordant HIV rapid tests were not infected. HIV prevalence varied considerably across the study sites (range: 0.6% to 24.4%). TRIAL REGISTRATION: ClinicalTrials.gov registry number NCT00203749. BioMed Central 2011-09-24 /pmc/articles/PMC3198953/ /pubmed/21943026 http://dx.doi.org/10.1186/1471-2334-11-251 Text en Copyright ©2011 Piwowar-Manning et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Piwowar-Manning, Estelle
Fiamma, Agnes
Laeyendecker, Oliver
Kulich, Michal
Donnell, Deborah
Szekeres, Greg
Robins-Morris, Laura
Mullis,, Caroline E
Vallari, Ana
Hackett, John
Mastro, Timothy D
Gray, Glenda
Richter, Linda
Alexandre, Michel W
Chariyalertsak, Suwat
Chingono,, Alfred
Sweat, Michael
Coates, Thomas
Eshleman, Susan H
HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_full HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_fullStr HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_full_unstemmed HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_short HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)
title_sort hiv surveillance in a large, community-based study: results from the pilot study of project accept (hiv prevention trials network 043)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198953/
https://www.ncbi.nlm.nih.gov/pubmed/21943026
http://dx.doi.org/10.1186/1471-2334-11-251
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