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L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer

BACKGROUND: The L1 cell adhesion molecule (L1CAM) is potentially involved in epithelial-mesenchymal transition (EMT). EMT marker expression is of prognostic significance in non-small cell lung cancer (NSCLC). The relevance of L1CAM for NSCLC is unclear. We investigated the protein expression of L1CA...

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Autores principales: Tischler, Verena, Pfeifer, Marco, Hausladen, Silke, Schirmer, Uwe, Bonde, Anne-Katrine, Kristiansen, Glen, Sos, Martin L, Weder, Walter, Moch, Holger, Altevogt, Peter, Soltermann, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198986/
https://www.ncbi.nlm.nih.gov/pubmed/21985405
http://dx.doi.org/10.1186/1476-4598-10-127
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author Tischler, Verena
Pfeifer, Marco
Hausladen, Silke
Schirmer, Uwe
Bonde, Anne-Katrine
Kristiansen, Glen
Sos, Martin L
Weder, Walter
Moch, Holger
Altevogt, Peter
Soltermann, Alex
author_facet Tischler, Verena
Pfeifer, Marco
Hausladen, Silke
Schirmer, Uwe
Bonde, Anne-Katrine
Kristiansen, Glen
Sos, Martin L
Weder, Walter
Moch, Holger
Altevogt, Peter
Soltermann, Alex
author_sort Tischler, Verena
collection PubMed
description BACKGROUND: The L1 cell adhesion molecule (L1CAM) is potentially involved in epithelial-mesenchymal transition (EMT). EMT marker expression is of prognostic significance in non-small cell lung cancer (NSCLC). The relevance of L1CAM for NSCLC is unclear. We investigated the protein expression of L1CAM in a cohort of NSCLC patients. L1CAM protein expression was correlated with clinico-pathological parameters including survival and markers of epithelial-mesenchymal transition. RESULTS: L1CAM protein expression was found in 25% of squamous cell carcinomas and 24% of adenocarcinomas and correlated with blood vessel invasion and metastasis (p < 0.05). L1CAM was an independent predictor of survival in a multivariate analysis including pT, pN, and pM category, and tumor differentiation grade. L1CAM expression positively correlated with vimentin, beta-catenin, and slug, but inversely with E-cadherin (all p-values < 0.05). E-cadherin expression was higher in the tumor center than in the tumor periphery, whereas L1CAM and vimentin were expressed at the tumor-stroma interface. In L1CAM-negative A549 cells the L1CAM expression was upregulated and matrigel invasion was increased after stimulation with TGF-beta1. In L1CAM-positive SK-LU-1 and SK-LC-LL cells matrigel invasion was decreased after L1CAM siRNA knockdown. CONCLUSIONS: A subset of NSCLCs with vessel tropism and increased metastasis aberrantly expresses L1CAM. L1CAM is a novel prognostic marker for NSCLCs that is upregulated by EMT induction and appears to be instrumental for enhanced cell invasion.
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spelling pubmed-31989862011-10-23 L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer Tischler, Verena Pfeifer, Marco Hausladen, Silke Schirmer, Uwe Bonde, Anne-Katrine Kristiansen, Glen Sos, Martin L Weder, Walter Moch, Holger Altevogt, Peter Soltermann, Alex Mol Cancer Research BACKGROUND: The L1 cell adhesion molecule (L1CAM) is potentially involved in epithelial-mesenchymal transition (EMT). EMT marker expression is of prognostic significance in non-small cell lung cancer (NSCLC). The relevance of L1CAM for NSCLC is unclear. We investigated the protein expression of L1CAM in a cohort of NSCLC patients. L1CAM protein expression was correlated with clinico-pathological parameters including survival and markers of epithelial-mesenchymal transition. RESULTS: L1CAM protein expression was found in 25% of squamous cell carcinomas and 24% of adenocarcinomas and correlated with blood vessel invasion and metastasis (p < 0.05). L1CAM was an independent predictor of survival in a multivariate analysis including pT, pN, and pM category, and tumor differentiation grade. L1CAM expression positively correlated with vimentin, beta-catenin, and slug, but inversely with E-cadherin (all p-values < 0.05). E-cadherin expression was higher in the tumor center than in the tumor periphery, whereas L1CAM and vimentin were expressed at the tumor-stroma interface. In L1CAM-negative A549 cells the L1CAM expression was upregulated and matrigel invasion was increased after stimulation with TGF-beta1. In L1CAM-positive SK-LU-1 and SK-LC-LL cells matrigel invasion was decreased after L1CAM siRNA knockdown. CONCLUSIONS: A subset of NSCLCs with vessel tropism and increased metastasis aberrantly expresses L1CAM. L1CAM is a novel prognostic marker for NSCLCs that is upregulated by EMT induction and appears to be instrumental for enhanced cell invasion. BioMed Central 2011-10-10 /pmc/articles/PMC3198986/ /pubmed/21985405 http://dx.doi.org/10.1186/1476-4598-10-127 Text en Copyright ©2011 Tischler et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tischler, Verena
Pfeifer, Marco
Hausladen, Silke
Schirmer, Uwe
Bonde, Anne-Katrine
Kristiansen, Glen
Sos, Martin L
Weder, Walter
Moch, Holger
Altevogt, Peter
Soltermann, Alex
L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
title L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
title_full L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
title_fullStr L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
title_full_unstemmed L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
title_short L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer
title_sort l1cam protein expression is associated with poor prognosis in non-small cell lung cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198986/
https://www.ncbi.nlm.nih.gov/pubmed/21985405
http://dx.doi.org/10.1186/1476-4598-10-127
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