Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review

BACKGROUND: Chordomas are very rare low-grade malignant bone tumors that arise from the embryonic rests of the notochord. They are characterized by slow growth and long history with frequent local relapses, and sometimes metastases. While chemotherapy is not efficient, imatinib has shown antitumor a...

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Autores principales: Launay, Simon G, Chetaille, Bruno, Medina, Fanny, Perrot, Delphine, Nazarian, Serge, Guiramand, Jérôme, Moureau-Zabotto, Laurence, Bertucci, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199017/
https://www.ncbi.nlm.nih.gov/pubmed/21970335
http://dx.doi.org/10.1186/1471-2407-11-423
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author Launay, Simon G
Chetaille, Bruno
Medina, Fanny
Perrot, Delphine
Nazarian, Serge
Guiramand, Jérôme
Moureau-Zabotto, Laurence
Bertucci, François
author_facet Launay, Simon G
Chetaille, Bruno
Medina, Fanny
Perrot, Delphine
Nazarian, Serge
Guiramand, Jérôme
Moureau-Zabotto, Laurence
Bertucci, François
author_sort Launay, Simon G
collection PubMed
description BACKGROUND: Chordomas are very rare low-grade malignant bone tumors that arise from the embryonic rests of the notochord. They are characterized by slow growth and long history with frequent local relapses, and sometimes metastases. While chemotherapy is not efficient, imatinib has shown antitumor activity. CASE PRESENTATION: We report on a 76-year-old patient with EGFR-overexpressing advanced chordoma that progressed on imatinib and subsequently responded to erlotinib during 12 months. CONCLUSIONS: We report the fourth case of advanced chordoma treated with an EGFR inhibitor. We also review the literature concerning the rationale and potential of EGFR targeting in chordoma.
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spelling pubmed-31990172011-10-23 Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review Launay, Simon G Chetaille, Bruno Medina, Fanny Perrot, Delphine Nazarian, Serge Guiramand, Jérôme Moureau-Zabotto, Laurence Bertucci, François BMC Cancer Case Report BACKGROUND: Chordomas are very rare low-grade malignant bone tumors that arise from the embryonic rests of the notochord. They are characterized by slow growth and long history with frequent local relapses, and sometimes metastases. While chemotherapy is not efficient, imatinib has shown antitumor activity. CASE PRESENTATION: We report on a 76-year-old patient with EGFR-overexpressing advanced chordoma that progressed on imatinib and subsequently responded to erlotinib during 12 months. CONCLUSIONS: We report the fourth case of advanced chordoma treated with an EGFR inhibitor. We also review the literature concerning the rationale and potential of EGFR targeting in chordoma. BioMed Central 2011-10-04 /pmc/articles/PMC3199017/ /pubmed/21970335 http://dx.doi.org/10.1186/1471-2407-11-423 Text en Copyright ©2011 Launay et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Launay, Simon G
Chetaille, Bruno
Medina, Fanny
Perrot, Delphine
Nazarian, Serge
Guiramand, Jérôme
Moureau-Zabotto, Laurence
Bertucci, François
Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
title Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
title_full Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
title_fullStr Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
title_full_unstemmed Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
title_short Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
title_sort efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199017/
https://www.ncbi.nlm.nih.gov/pubmed/21970335
http://dx.doi.org/10.1186/1471-2407-11-423
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